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  4. Vol 3, Issue 6, 2023

Study on the Related Mechanism of Insomnia

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DOI: 10.23977/phpm.2023.030610 | Downloads: 14 | Views: 292

Author(s)

Fangyuan Chen 1, Hai Lin 1

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China

Corresponding Author

Hai Lin

ABSTRACT

As a physiological activity, good sleep is of great significance to people's life and work. In recent years, with the advancement of science and technology and the acceleration of the pace of life, people's schedules have changed, and staying up late and going to bed late have become more and more common in big cities. Work stress, along with life stress, increases the incidence of insomnia. This rapidly rising incidence of insomnia has gradually become a social problem from affecting the life and work of individuals. Insomnia has begun to attract people's attention, and more and more scientists and doctors have begun to study the onset and treatment of insomnia. Many studies have explored the mechanisms involved in insomnia in many ways. In this review, we will explore the mechanism of insomnia and its mechanism-related signaling pathways from five aspects: immune function, oxidative stress state, inflammatory response, apoptosis, and brain-gut axis system. Through the collation of research data, it was found that the mRNA expression level of TLR-related genes decreased, which could improve insomnia in rats. Reducing the levels of SOD and nos in rats can prolong the duration of insomnia; increasing the content of cAMP in rat hypothalamus can improve sleep in rats; increasing the expression of Bcl-2 protein and decreasing Bax protein in rats can improve sleep. Reducing Fas/FasL protein in rats can improve sleep quality; the gut microbiota can affect sleep in rats.

KEYWORDS

Insomnia, Mechanism, Immune Function, Oxidative Stress, Inverse Reaction, Cell Apoptosis, Cerebrointestinal Axis, Signal Path

CITE THIS PAPER

Fangyuan Chen, Hai Lin, Study on the Related Mechanism of Insomnia. MEDS Public Health and Preventive Medicine (2023) Vol. 3: 65-71. DOI: http://dx.doi.org/10.23977/phpm.2023.030610.

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