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Progress in the treatment of advanced triple-negative breast cancer

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DOI: 10.23977/medsc.2023.040812 | Downloads: 8 | Views: 312


Hao Zhao 1, Xie Li 2, Wu Yingying 1


1 Department of Oncology, The Second Naval Hospital of the Southern Theater Command of PLA, Sanya, China
2 Department of Anesthesiology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, China

Corresponding Author

Wu Yingying


Three negative breast cancer (TNBC) refers to breast cancer with negative estrogen receptor, progesterone receptor and proto oncogene human epidermal growth factor receptor-2 in immunohistochemical examination of cancer tissue. It is a molecular subtype of breast cancer, with poor histopathological grading, high malignancy, strong invasion, prone to visceral metastasis and brain metastasis, high recurrence rate and strong heterogeneity. Due to its unique biological behavior and clinical pathological characteristics, there are still many deficiencies in treatment methods, and its prognosis is worse than other types. In recent years, with the discovery of special targets and the invention of targeted, immune and antibody conjugated drugs, precision therapy drugs have been gradually applied to the treatment of advanced triple negative breast cancer, which has the characteristics of specificity, efficiency, safety, etc. In traditional Chinese medicine, breast cancer belongs to the category of "milk rock". The treatment is guided by the idea of relative unity of form and spirit, and the principle of combining strengthening the body and expelling pathogens is used to improve the symptoms of patients. These different drugs have shown good anti-tumor activity when used for advanced triple negative breast cancer.


Three negative breast cancer; targeted drugs; immunocheckpoint inhibitor; traditional Chinese medicine


Hao Zhao, Xie Li, Wu Yingying, Progress in the treatment of advanced triple-negative breast cancer. MEDS Clinical Medicine (2023) Vol. 4: 80-86. DOI:


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