Author(s)

Tian Lihua ¹, Liu Jiale ¹, Wang Chen ¹, Chen Mengjie ², Yao Jia ²

Affiliation(s)

¹ Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
² Xi'an Traditional Chinese Medicine Hospital, Xi'an, Shaanxi, 710021, China

Corresponding Author

Chen Mengjie

ABSTRACT

To observe the clinical efficacy of Quyu Jiedu Xiaozheng Tang combined with Diqu Progesterone Tablets in the treatment of patients with endometriosis, and to analyze the serum MIF and TGF of patients- β the impact of 1. 60 EM patients were selected and randomly divided into a traditional Chinese medicine group, a combination of traditional Chinese and Western medicine group, and a western medicine group, with 20 cases each. The traditional Chinese medicine group was given oral Quyu Jiedu Xiaozheng Tang; The Western medicine group was given oral Dafu Tong (Diqu Progesterone Tablets); The combination of traditional Chinese and Western medicine group was given a combined oral administration of Quyu Jiedu Xiaozheng Tang and Diqu Progesterone Tablets. After three consecutive months of treatment, the clinical efficacy and total effective rate of the three groups of patients were compared. Enzyme linked immunosorbent assay (ELISA) was used to detect the levels of macrophage migration inhibitory factor (MIF) and transforming growth factor (TGF) in the serum of the three groups of patients before and after treatment- β 1 level. The total effective rate (95%) of clinical efficacy in the combination of traditional Chinese and Western medicine group is better than that in the traditional Chinese medicine group (90%) and the western medicine group (90%); After treatment, the serum MIF levels of the three groups of patients were significantly reduced compared to before treatment, and P (0.033) in the combination of Chinese and Western medicine group was lower than P (0.036) in the traditional Chinese medicine group and P (0.036) in the western medicine group; Serum TGF of the three groups after treatment- β All levels were significantly lower than before treatment, and P (0.035) in the combination of traditional Chinese and Western medicine group was lower than P (0.043) in the traditional Chinese medicine group and P (0.042) in the western medicine group. The P-values are all<0.05, indicating significant significance in the experiment. Conclusion: Quyu Jiedu Xiaozheng Tang combined with Diqu Progesterone Tablets can effectively alleviate the clinical symptoms of patients with endometriosis, and can reduce the serum MIF and TGF of patients- β At the first level, the clinical effect of combining traditional Chinese and Western medicine in treating EM is more significant than that of traditional Chinese medicine and Western medicine alone. Its mechanism of action may be related to the regulation of macrophage migration inhibitory factor MIF and transforming growth factor TGF- β 1. Related.

KEYWORDS

Apply Quyu Jiedu Xiaozheng Tang and Diqu Progesterone Tablets to treat endometriosis, and pay attention to the patient's serum MIF and TGF before and after treatment- β value change of 1

CITE THIS PAPER

Tian Lihua, Liu Jiale, Wang Chen, Chen Mengjie, Yao Jia, The Therapeutic Effect of Quyu Jiedu Xiaozheng Tang Combined with Diqu Progesterone Tablets on Endometriosis and Its Effect on Serum MIF and TGF- Β Impact Of 1. MEDS Chinese Medicine (2023) Vol. 5: 192-200. DOI: http://dx.doi.org/10.23977/medcm.2023.051026.

REFERENCES

[1] Obstetricians and Gynecologists Branch of the Chinese Medical Association, Endometriosis Collaborative Group of the Obstetrics and Gynecology Branch of the Chinese Medical Association. Guidelines for the Diagnosis and Treatment of Endometriosis in Children (Third Edition) [J]. Chinese Journal of Obstetrics and Gynecology, 2021, 56 (12): 812-824
[2] Becker Cm, Bokor A, Heikinheimo O, et al. ESHRE guide: endpoints [J] Hum Reprod Open, 2022,2022 (2): hoac009. dOi: 10. 1093/hropen/hoac009
[3] Zhang Xiaofeng, Dong Liyun, Wang Qing. Treatment of 45 Cases of Endometriosis with Quyu Jiedu Xiaozheng Tang [J]. Shaanxi Traditional Chinese Medicine, 2009, 30 (03): 260-261
[4] Endometriosis Professional Committee of the Obstetricians and Gynecologists Branch of the Chinese Medical Association, Endometriosis Collaborative Group of the Obstetrics and Gynecology Branch of the Chinese Medical Association. Chinese Expert Consensus on Long term Management of Endometriosis [J]. Chinese Journal of Obstetrics and Gynecology, 2018, 53 (12): 836-840
[5] Endometriosis Collaborative Group, Obstetrics and Gynecology Branch, Chinese Medical Association. Guidelines for the diagnosis and treatment of endometriosis [J]. Chinese Journal of Obstetrics and Gynecology, 2015, 50 (3): 161-169
[6] Chinese Society of Integrated Traditional and Western Medicine Obstetrics and Gynecology Professional Committee, Diagnosis and Treatment Standards for Endometriosis, Pregnancy Induced Hypertension Syndrome, and Female Infertility [J]. Journal of Integrated Traditional and Western Medicine, 1991, 11 (6): 376-379
[7] Edited by Tan Yong. Traditional Chinese Gynecology [M]. 4th edition. Beijing: China Traditional Chinese Medicine Press, 2017:276-282
[8] Zhang Na. Progress in Etiological Research on Endometriosis [J]. Practical Clinical Medicine, 2016, 17 (01): 104-107. DOI: 10. 13764/j. cnki. lcsy. 2016. 01. 038
[9] Xiao Shan, Zhao Li, Xu Lianwei, et al. Blood stasis and endometriosis [J]. Henan Traditional Chinese Medicine, 2022, 42 (10): 1506-1509. DOI: 10. 16367/j. issn. 1003-5028. 2022. 10. 318
[10] Wang Wei, Ren Qingling, Li Jianmei, et al. Fu Youfeng's Experience in Treating Endometriosis from the Perspective of Dampness, Turbidity, Stasis and Toxicity [J]. Jiangsu Traditional Chinese Medicine, 2022, 54 (10): 33-36. DOI: 10. 19844/j. cnki. 1672-397X. 2022, 10. 012
[11] Xie Dandan, Cao Yang, Zhuang Mengfei, et al. Research progress on endometriosis of qi stagnation and blood stasis type [J]. Journal of Traditional Chinese Medicine, 2021, 49 (07): 101-105. DOI: 10. 19664/j. cnki. 1002-2392. 210173
[12] Yang Dongxia, Wang Ning, Huo Yuxia, et al. Research progress on the treatment of endometriosis from dampness heat stasis [J]. Journal of Traditional Chinese Medicine, 2021, 49 (07): 116-120. DOI: 10. 19664/j. cnki. 1002-2392. 210176
[13] Guan Lilan, Zhou Ying. Application of warming yang and dispersing stasis method based on the theory of "yang deficiency and yin stasis" in the treatment of endometriosis [J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2021, 38 (03): 613-617. DOI: 10. 13359/j. cnki. gzxbtcm. 2021. 03. 032
[14] Wang Xiao, You Zhaoling. Analysis of Professor You Zhaoling's understanding of endometriosis and the characteristics of traditional Chinese medicine treatment [J]. Chinese Journal of Traditional Chinese Medicine, 2014, 29 (08): 2457-2460
[15] Zhao Xiaoxuan, Zhang Yang, Yang Qiaorui, etc. The application of "all pain and itching ulcers belong to the heart" in the treatment of endometriosis dysmenorrhea [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 36 (10): 2459-2462. DOI: 10. 13193/j. issn. 1673-7717. 2018. 10. 039
[16] Liu X, Ying W, Puwei S, et al. Sargentodoxa cuneata and Patrinia villosa extract inhibits LPS induced inflation by shifting microstructures polarization through FAK/PI3K/Akt pathway regulation and glucose metabolism reprogramming [J]. Journal of Ethnopharmacology, 2023, 318 (PA) 
[17] Ni Zhexin, Zhao Qianqian, Sun Shuai, et al. Analysis of the mechanism of action of Da Xueteng in the treatment of endometriosis based on network pharmacology [J]. New Chinese Medicine, 2020, 52 (24): 9-13. DOI: 10. 13457/j. cnki. jncm. 2020. 24. 003. 
[18] Li Man, Zhang Lurong, Jin Shunqi, et al. Comparative study on anti-inflammatory and analgesic effects and chemical components of different extracts of Hedyotis diffusa [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2022, 24 (08): 19-23. DOI: 10. 13194/j. issn. 1673-842x. 2022. 08. 005. 
[19] Wang Jun, Xu Chuanhua. Study on the mechanism of action of "Ghost Arrow Feather White Flower Snake Tongue Grass" in the treatment of endometriosis based on network pharmacology and molecular docking [J]. Medical Information, 2023, 36 (09): 21-29
[20] Chen Shi, Zhao Yue, Wang Zhen, et al. Research progress on pharmacological effects and clinical applications of Shancigu [J]. Chinese Journal of Traditional Chinese Medicine, 2023, 41 (06): 247-250. DOI: 10. 13193/j. issn. 1673-7717. 2023. 06. 054
[21] Zhao Lihui, Zhao Zizhang, Li Jiachen, et al. Study on the anti-inflammatory and analgesic effects and mechanisms of active ingredients KTDA, FSA and their compatibility in frankincense and myrrh [J]. New Chinese Medicine and Clinical Pharmacology, 2022, 33 (11): 1460-1465. DOI: 10. 19378/j. issn. 1003-9783. 2022. 11. 003
[22] Su Shulan, Miao Xiaodong, Li Jiachen et al. Analysis of the compatibility characteristics of frankincense and myrrh and its modern research progress and prospects [J]. Chinese Journal of Traditional Chinese Medicine, 2022, 47 (21): 5789-5796. DOI: 10. 19540/j. cnki. cjcmm. 20220801. 601
[23] Yang L, Liu X, Zhang N, et al. Flavonoids in Resina Draconis protect against pulmonary fibrosis via the TGF- β 1TCH1 path [J] Molecular&Cellular Toxicology, 2020, 16 (2)
[24] Ji Lili, Lv Shaowa, Yang Zhixin. Research progress on chemical components and pharmacological effects of centipedes [J]. Specialty Research, 2020, 42 (04): 75-84. DOI: 10. 16720/j. cnki. tcyj. 2020. 04. 013
[25] Xu Longsheng, Feng Qinli, Zhang Xiaoping, et al. Experimental Study on the Analgesic Effect and Toxic Side Effects of Centipede and Scorpion Powder [J]. Chinese Journal of General Medicine, 2018, 16 (03): 346-348. DOI: 10. 16766/j. cnki. issn. 1674-4152. 000096
[26] Yunnuo L, Zhuo L, Ying L, et al. Total flavonoids of Litchi seed attenuate stem cell like properties in breast cancer by regulating Notch3 signaling path [J]. Journal of Ethnopharmacology, 2023305
[27] Zahra C, Maryam S, Reza A, et al. The Relationship between Functional Promoter Variables of Macrophage Migration Inhibitory Factor and Endometriosis [J]. Cell journal, 2021, 22 (4)
[28] Yang Qingchun. Expression and significance of macrophage migration inhibitory factor, vascular endothelial growth factor, and receptor in tissues and serum of patients with endometriosis [J]. Hebei Medical Journal, 2015, 37 (17): 2583-2586
[29] Elbaradie Y M S, Bakry S M, Bosilah H A. Serum macrophage migration inhibition factor for diagnosing endometriosis and its severity: case control study [J]. BMC women's health, 2020, 20 (1)
[30] Li Hui, Wu Suhui, Zhang Suyu. Research progress on macrophage migration inhibitory factor in gynecological malignant tumors [J]. International Journal of Obstetrics and Gynecology, 2015, 42 (05): 571-574
[31] Li Fengmei, Zhang Hanke, Li Yanhui TGF- β 1. Promoting the migration and invasion of endometrial stromal cells in endometriosis by inducing metabolic recombination [J]. Modern Obstetrics and Gynecology Progress, 2019, 28 (02): 81-85. DOI: 10. 13283/j. cnki. xdfckjz. 2019. 02. 001
[32] Zhou Wei, She Liping, Ji Yazhong, etc. MCP-1, HGF, TGF- β the expression and significance of 1 in endometriosis [J]. Journal of Tongji University (Medical Edition), 2015, 36 (01): 63-66. DOI: 10. 16118/j. 1008-0392. 2015-01. 014
[33] Xie G, Lei D, He H, et al. Relationship between serum TGF- β 1. OPG levels and orthoporotic risk in native Chinese women [J]. Clinica Chimica Acta, 2013423
[34] Shuyan C, Jianwei Z, Huimin S, et al. Relationship between serum TGF- β 1, MMP-9 and IL-1β and pathological features and prognosis in breast cancer[J]. Frontiers in Genetics, 2023, 13

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