Author(s)

Yirong Zhang ¹, Yongjun Li ¹, Yifeng Tang ¹, Li Liu ¹

Affiliation(s)

¹ Department of Cardiovascular Medicine, Liupanshui People's Hospital, Liupanshui, Guizhou, 553001, China

Corresponding Author

Yirong Zhang

ABSTRACT

This paper discusses the application characteristics of biodegradable materials in blocking devices related to congenital heart disease, and details the characteristics of levo-polylactic acid (PLLA), polyglycolic acid (PGA, PGA), polycaprolactone (PCL), poly-dioxycyclohexanone (PDO) and other materials and their application in the treatment of congenital heart disease. These materials have good biocompatibility and degradability, suitable for the production of congenital heart disease related device. Through animal experiments and clinical observation, the degradable occluder shows good safety and efficacy in the interventional treatment of congenital heart disease. For example, studies of PLL and PDO devices showed that these occluder effectively performed endothelialization after implantation and showed good biocompatibility and degradability. However, some occluder materials such as PCL have limitations in flexibility and require further improvement. Therefore, as a new option for heart disease, but more research is still needed to improve its performance and application.

KEYWORDS

Degradable occluder; congenital heart disease; interventional therapy

CITE THIS PAPER

Yirong Zhang, Yongjun Li, Yifeng Tang, Li Liu, Study on the application of degradable occluder in the interventional treatment of congenital heart disease. MEDS Clinical Medicine (2024) Vol. 5: 14-19. DOI: http://dx.doi.org/10.23977/medsc.2024.050103.

REFERENCES

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