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  4. Vol 5, Issue 1, 2024

Advances in signaling pathways and targets of fibroblast-like synoviocytes in rheumatoid arthritis

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DOI: 10.23977/medsc.2024.050108 | Downloads: 5 | Views: 112

Author(s)

Huixiang Chen 1, Jiabin Chen 2, Kaijun Wang 3, Xuecheng Xu 1, Shule Cui 3, Lihua Wang 2

Affiliation(s)

1 Zhengzhou Gout and Rheumatology Hospital, Zhengzhou, Henan, China
2 Harbin Ankylosing Hospital, Harbin, Heilongjiang, China
3 Nanjing Pain Ten Phoenix Hospital, Nanjing, Jiangsu, China

Corresponding Author

Huixiang Chen

ABSTRACT

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease significantly characterized by the abnormal proliferation and activation of fibroblast-like synoviocytes (FLS) in the synovial membrane. Studies have shown that FLS play an important role in the development and are involved in pathological processes such as inflammatory response, bone destruction and synovial proliferation. In this paper, we review the recent research progress of FLS signaling pathways, including inflammation-related signaling pathways, apoptosis and survival signaling pathways, and cell migration and invasion signaling pathways. In addition, we discuss the potential therapeutic targets of FLS signaling pathways. By discussing these research advances in depth, we hope to provide new ideas and directions for the treatment of RA.

KEYWORDS

Rheumatoid arthritis, fibroblast-like synoviocytes, signal pathways, targets

CITE THIS PAPER

Huixiang Chen, Jiabin Chen, Kaijun Wang, Xuecheng Xu, Shule Cui, Lihua Wang, Advances in signaling pathways and targets of fibroblast-like synoviocytes in rheumatoid arthritis. MEDS Clinical Medicine (2024) Vol. 5: 44-48. DOI: http://dx.doi.org/10.23977/medsc.2024.050108.

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