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The clinical value of the systemic immune-inflammation index for major pathological response in non-small cell lung cancer patients receiving neoadjuvant chemoimmunotherapy

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DOI: 10.23977/tranc.2024.050102 | Downloads: 8 | Views: 371


Yang Xiang 1, Li Chen 1


1 Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Corresponding Author

Li Chen


This study attempted to investigate the clinical value of systemic immune-inflammation index (SII) for Major Pathologic Response (MPR) in non‑small cell lung cancer(NSCLC) patients receiving neoadjuvant chemoimmunotherapy. A total of 56 non‑small cell lung cancer patients who were diagnosed and received neoadjuvant chemoimmunotherapy in the First Affiliated Hospital of Chongqing Medical University from April 2019 to April 2023 December 2023 were retrospectively analyzed,all patients were divided into the MPR group (35 cases) and No-MPR group (21 cases) according to their postoperative pathological results. The baseline neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-infammation index (SII) and clinicopathological variables were assessed for their association with MPR.The receiver operating characteristic (ROC) curve analysis and area under the ROC curve (AUC) values were used to evaluate the optimal cutoff values of the NLR,PLR and SII,and independent influencing factors of postoperative MPR were analyzed by binary logistic regression. Results indicated that NLR, PLR, and SII levels were significantly lower in the MPR group compared to those of the No-MPR group (P<0.05).The results of the ROC analysis showed that the area under the curve for the NLR,PLR and SII were 0.794,0.728and 0.838,respectively. Univariate Logistic regression analysis showed that the NLR, PLR, and SII level were significantly related to MPR (P<0.05).According to multivariate Logistic regression analysis,only SII level(OR=0.12,95%CI 0.02-0.17,P=0.019) was independent influence factors for MPR. In conclusion, NSCLC patients with low SII level (<947.6) are more likely to achieve MPR receiving neoadjuvant chemoimmunotherapy. It is likely to become a clinical monitoring index for the efficacy of neoadjuvant chemoimmunotherapy.


Non-small cell lung cancer; Neoadjuvant therapy; Major pathological response; systemic immune-inflammation index; clinical value


Yang Xiang, Li Chen, The clinical value of the systemic immune-inflammation index for major pathological response in non-small cell lung cancer patients receiving neoadjuvant chemoimmunotherapy. Transactions on Cancer (2024) Vol. 5: 8-17. DOI:


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