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Relationship between Serum Bilirubin Level and the Prevalence of Lung Cancer in Smokers

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DOI: 10.23977/tranc.2024.050104 | Downloads: 11 | Views: 313


Mohan Li 1, Weilin Liu 2


1 Department of Internal Medicine, Peking Union Medical College Hospital, Beijing, China
2 Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China

Corresponding Author

Weilin Liu


The correlation between serum bilirubin level and multiple respiratory system diseases including lung cancer has been reported. We aimed to explore the relationship between serum bilirubin level and the prevalence of lung cancer among smokers in China. Therefore, a retrospective case-control study and enrolled 266 lung cancer patients and 266 matched controls from The Third Xiangya Hospital of Central South University from February 2011 to May 2017 was designed. Data including diagnosis, serum bilirubin levels and smoking history were collected, which consistently showed significant differential in cases and controls. We found lower total and indirect bilirubin level is correlated with smoking but they can be recuperating after cessation. The average bilirubin level in lung cancer patients was lower than matched controls, while lower indirect bilirubin level within normal range is the risk factor of lung cancer in smokers (OR = 2.710). Of note, smokers whose serum indirect bilirubin lower than 7.88 μmol / L has a higher risk of lung cancer in Chinese adults. In conclusions, serum indirect bilirubin level would be a screening predictor to identify higher risk smokers of lung cancer.


Bilirubin level; Lung cancer; Smoking; Early cancer screening; Bio-marker


Mohan Li, Weilin Liu, Relationship between Serum Bilirubin Level and the Prevalence of Lung Cancer in Smokers. Transactions on Cancer (2024) Vol. 5: 28-33. DOI:


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