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Effect of Intensity Level on Dose in Intensity-modulated Radiotherapy for Nasopharyngeal Carcinoma

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DOI: 10.23977/tranc.2024.050105 | Downloads: 11 | Views: 264

Author(s)

Juan Deng 1

Affiliation(s)

1 Department of Oncology, Deyang People's Hospital, Deyang, Sichuan, China

Corresponding Author

Juan Deng

ABSTRACT

To make intensity-modulated radiotherapy (IMRT) planning for nasopharyngeal carcinoma based on XIO planning system through adjusting values of intensity level, and provide a basis for the selection of the value of intensity level. 30 patients with nasopharyngeal carcinoma were randomly enrolled. Eight IMRT plans were made for each case using ELEKTA XIO 4.64 TPS, with the application of 7evenly distributed fixed incidence directions (153, 102, 51, 0, 309, 258, 207), a minimum segment length of 2cm and a minimum sub-field monitor units (MUs) of 5 MU.All plans were optimized with intensity levels from 20 to 5 respectively, using SWO tool to optimize sub-field weight. The dose-volume histogram was used to evaluate the dose distribution in target volume (PTV) and organs at risk (OAR). With the level value decreasing from 20 to 5, the total number of segments of IMRT plans was decreased from(186±16) to(58±7)(F=352.4, P<0.001). All plans ranged from 20 to 7 were no significant dosimetry differences on parameters of PTV and OAR (P>0.05) through comparing between any two plans, but the number of segments was reduced to (87±6). Using ELEKTA XIO treatment planning system to make IMRT plan for nasopharyngeal Carcinoma, the plan can still reach requirement for clinical dose with intensity level 7, and there is a significant reduction in the total number of segments.

KEYWORDS

Nasopharyngeal Carcinoma; intensity-modulated radiotherapy; intensity level; the total number of segments; monitor units

CITE THIS PAPER

Juan Deng, Effect of Intensity Level on Dose in Intensity-modulated Radiotherapy for Nasopharyngeal Carcinoma. Transactions on Cancer (2024) Vol. 5: 34-38. DOI: http://dx.doi.org/10.23977/tranc.2024.050105.

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