The Application Value of Serum Cytokine Levels in Assessing the Disease Activity of Inflammatory Bowel Disease
DOI: 10.23977/medsc.2024.050213 | Downloads: 7 | Views: 81
Author(s)
Yang Shen 1
Affiliation(s)
1 Deyang People's Hospital, Deyang, Sichuan, 618000, China
Corresponding Author
Yang ShenABSTRACT
This study aims to explore the application value of serum cytokine levels (TNF-α, IL-6, IL-10, IFN-γ) and disease activity scores in assessing the disease activity of inflammatory bowel disease (IBD). This experiment adopts a prospective study design, with a total of 100 subjects, including 50 IBD patients (experimental group) and 50 healthy controls (control group), over a duration of 6 months. The levels of TNF-α, IL-6, IL-10, and IFN-γ in serum were measured using the ELISA method, while the disease activity scores of patients were recorded. Data processing was carried out using SPSS software, and a P value of less than 0.05 was considered statistically significant. The levels of TNF-α, IL-6, IFN-γ, and Mayo scores in the experimental group were significantly higher than those in the control group (P < 0.05), while the level of IL-10 was significantly lower than that in the control group (P < 0.05). These results indicate that IBD patients have significant inflammatory responses and higher disease activity. The elevation of TNF-α, IL-6, and IFN-γ in serum, along with the reduction of IL-10 and the increase in disease activity scores, can serve as effective indicators for assessing the disease activity of IBD. The detection of these biomarkers is of great significance for the diagnosis and treatment monitoring of IBD.
KEYWORDS
Inflammatory bowel disease; TNF-α; IL-6; IL-10; IFN-γCITE THIS PAPER
Yang Shen, The Application Value of Serum Cytokine Levels in Assessing the Disease Activity of Inflammatory Bowel Disease . MEDS Clinical Medicine (2024) Vol. 5: 84-88. DOI: http://dx.doi.org/10.23977/medsc.2024.050213.
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