Author(s)

Naizhuang Wang ¹, Jingjing Dai ¹, Binbin Song ¹, Waifun Mok ¹

Affiliation(s)

¹ Eternal Grace PTE. LTD, 128 Tuas South Avenue 3#01-05, JTC Space @ Tuas Biomedical Park, 637370, Singapore

Corresponding Author

Jingjing Dai

ABSTRACT

This paper investigates the oral intake of sheep placenta supplements on ovarian reserve markers, skin health, and menstrual regularity in women under the age of 40 with diminished ovarian reserve or premature ovarian insufficiency. Twenty-four eligible female participants were enrolled in an 8-week intervention study. The participants were administered two capsules daily of Biowell Placenta & DCI 40. Assessments of ovarian function included Anti-Müllerian Hormone (AMH), Follicle-Stimulating Hormone (FSH), Estradiol (E2), and Antral Follicle Count (AFC). Skin health was evaluated through participant self-assessment questionnaires pre- and post-intervention, focusing on elasticity, brightness, smoothness, and spot reduction. Menstrual cycle regularity and volume were also recorded.  Post-supplementation, a statistically significant increase was observed in AMH (from 1.44±1.61 to 1.68±1.37 ng/ml, p=0.00104) and AFC (from 4.37±1.02 to 4.89±3.30, p=0.0045). Skin health assessments showed significant improvement in elasticity, brightness, and smoothness, with visible spot reduction. Menstrual cycle regularity and volume also enhanced, indicating improved hormonal balance. No adverse events were reported, indicating a high tolerance for the supplement. The Biowell Placenta & DCI 40 capsules, utilizing the innovative NanoFiltration process, have demonstrated potential benefits in improving ovarian and skin health and menstrual cycle regularity. This advancement in extraction technology shows promise in enhancing the bioactive efficacy of sheep placenta products, offering a novel non-invasive approach for women's health and aging concerns. Further research is warranted to confirm these findings in larger, controlled trials.

KEYWORDS

Dietary supplement, Sheep placenta, Ovarian health, Anti-aging, Skin health

CITE THIS PAPER

Naizhuang Wang, Jingjing Dai, Binbin Song, Waifun Mok, Enhancing Ovarian Reserve and Dermatological Health with NanoFiltration-Enhanced Sheep Placenta Supplement: A Clinical Evaluation of Biowell Placenta & DCI 40. MEDS Clinical Medicine (2024) Vol. 5: 95-100. DOI: http://dx.doi.org/10.23977/medsc.2024.050215.

REFERENCES

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[2] Lee, M.K., Park, J.B., & Kim, J.Y. (2020). Effects of Oral Placenta Supplements on Hormonal Balance and Ovarian Function: A Preliminary Study. International Journal of Women's Health, 12, 45-53.
[3] Wang, H., & Liu, D. (2018). NanoFiltration Techniques in Traditional Medicine Extraction Processes. Journal of Traditional Medicine & Clinical Naturopathy, 7(2), 1-10.
[4] Kim, S.Y., Park, E.J., & Lee, S.H. (2021). Comparative Analysis of Anti-Aging Properties of Placental Extracts in Cosmeceutical Applications. Cosmetic Dermatology, 34(6), 1124-1132.
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[7] Zhao, L., Chen, Q., & Li, P. (2018). Advancements in NanoFiltration Technology for Extraction of Phytochemicals. Nanotechnology in Agriculture and Food Science, 2(1), 15-29.
[8] Kumar, A., & Singh, A. (2019). Influence of Dietary Supplements on Female Hormonal Health: A Systematic Review. Nutrition Research Reviews, 32(2), 233-248.
[9] Chen, X., & Zhou, H. (2021). Investigation of the Anti-Inflammatory Effects of Sheep Placenta Extracts. Inflammation Research, 70(9), 935-944.
[10] Morrison, T., & Wright, G. (2020). The Role of Traditional Remedies in Modern Day Healthcare: Sheep Placenta as a Case Study. Journal of Integrative Medicine, 18(5), 385-392.
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