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Clinical diagnostic value of serum ICAM-1, MMP-9, TNF-α and IL-6 in patients with early brain tumours

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DOI: 10.23977/tranc.2024.050107 | Downloads: 4 | Views: 201

Author(s)

Shichao Yuan 1

Affiliation(s)

1 School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

Corresponding Author

Shichao Yuan

ABSTRACT

The objective of the study is to analyse the value of serum-mediated levels of cell adhesion molecule-1 (ICAM-1), matrix metalloproteinase-9 (MMP-9), tumour necrosis factor-alpha (TNF)-alpha) and interleukin-6 (IL-6) in the early diagnosis of brain tumours. Serum samples were collected from 100 brain tumour patients and 100 healthy controls. The serum levels of ICAM-1, MMP-9 and TNF -α compared with IL-6 were detected by enzyme-linked immunosorbent assay (EIA), and the results were statistically analysed. The results show that the levels of ICAM-1, MMP-9 and TNF in serum of brain tumour patients- α IL-6 and IL-6 were significantly higher (P<0.01). The sensitivity and specificity of serum ICAM-1, MMP-9, and TNF- α IL-6 for the diagnostic thresholds determined by receiver operating characteristic curve (ROC) analysis were 85% and 80%, 78% and 84%, 82% and 76%, and 76% and 79%, respectively. CONCLUSION: Serum ICAM-1, MMP-9, TNF- α and IL-6 levels have high diagnostic value for the early diagnosis of brain tumours, and can be used as effective biomarkers for early screening and diagnosis of brain tumours.

KEYWORDS

Brain tumors; ICAM-1; MMP-9; TNF- α; IL-6

CITE THIS PAPER

Shichao Yuan, Clinical diagnostic value of serum ICAM-1, MMP-9, TNF-α and IL-6 in patients with early brain tumours. Transactions on Cancer (2024) Vol. 5: 47-52. DOI: http://dx.doi.org/10.23977/tranc.2024.050107.

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