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Clinical diagnostic value of serum ICAM-1, MMP-9, TNF-α and IL-6 in patients with early brain tumours

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DOI: 10.23977/tranc.2024.050107 | Downloads: 4 | Views: 201


Shichao Yuan 1


1 School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

Corresponding Author

Shichao Yuan


The objective of the study is to analyse the value of serum-mediated levels of cell adhesion molecule-1 (ICAM-1), matrix metalloproteinase-9 (MMP-9), tumour necrosis factor-alpha (TNF)-alpha) and interleukin-6 (IL-6) in the early diagnosis of brain tumours. Serum samples were collected from 100 brain tumour patients and 100 healthy controls. The serum levels of ICAM-1, MMP-9 and TNF -α compared with IL-6 were detected by enzyme-linked immunosorbent assay (EIA), and the results were statistically analysed. The results show that the levels of ICAM-1, MMP-9 and TNF in serum of brain tumour patients- α IL-6 and IL-6 were significantly higher (P<0.01). The sensitivity and specificity of serum ICAM-1, MMP-9, and TNF- α IL-6 for the diagnostic thresholds determined by receiver operating characteristic curve (ROC) analysis were 85% and 80%, 78% and 84%, 82% and 76%, and 76% and 79%, respectively. CONCLUSION: Serum ICAM-1, MMP-9, TNF- α and IL-6 levels have high diagnostic value for the early diagnosis of brain tumours, and can be used as effective biomarkers for early screening and diagnosis of brain tumours.


Brain tumors; ICAM-1; MMP-9; TNF- α; IL-6


Shichao Yuan, Clinical diagnostic value of serum ICAM-1, MMP-9, TNF-α and IL-6 in patients with early brain tumours. Transactions on Cancer (2024) Vol. 5: 47-52. DOI:


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