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The role of Nr1d1 in tumor

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DOI: 10.23977/tranc.2024.050109 | Downloads: 14 | Views: 139


Huang Chongzong 1


1 Zunyi Medical University, Zunyi, China

Corresponding Author

Huang Chongzong


REV-ERB receptor is a member of protein nuclear receptor superfamily, which is both intracellular receptor and transcription factor, so it regulates the expression of target gene. REV-ERB acts as a transcription inhibitor because of its unique structure. Their main function is to control the peripheral circadian rhythm by participating in the transcription-translation feedback loop with other major clock genes. As for their role in the pathogenesis of cancer, recent studies in various cancer tissues show that their expression is down-regulated in most cases. The imbalance of its expression is also related to cancer-related cachexia. The use of synthetic agonists can restore its pharmacological significance. Synthetic agonists have been explored in preclinical studies, but the data are scarce. It is necessary to further study, mainly through the mechanism study, the influence of REV-ERB-induced circadian rhythm disorder on carcinogenesis and cancer-related systemic effects (such as cachexia), in order to solve the potential problems of related therapeutic significance.


REV-ERB receptor, nuclear receptor, transcription factor, cancer


Huang Chongzong, The role of Nr1d1 in tumor. Transactions on Cancer (2024) Vol. 5: 63-71. DOI:


[1] Ka NL, Park MK, Kim SS, Jeon Y, Hwang S, Kim SM, Lim GY, Lee H, Lee MO. NR1D1 Stimulates Antitumor Immune Responses in Breast Cancer by Activating cGAS-STING Signaling. Cancer Res. 2023 Sep 15; 83(18):3045-3058. doi: 10.1158/0008-5472.CAN-23-0329. PMID: 37395684; PMCID: PMC10538367.
[2] Liu S, Cheng Y, Wang S, Liu H. Circadian clock genes modulate immune, cell cycle and apoptosis in the diagnosis and prognosis of pan-renal cell carcinoma. Front Mol Biosci. 2021; 8:747629.
[3] Wang X, Jia R, Chen K, Wang J, Jiang K, Wang Z. RORα and REV-ERBα are Associated With Clinicopathological Parameters and are Independent Biomarkers of Prognosis in Gastric Cancer. Technol Cancer Res Treat. 2021 Jan-Dec; 20:15330338211039670. doi: 10.1177/15330338211039670. PMID: 34931925; PMCID: PMC8721360.
[4] Basti A, Malhan D, Dumbani M, Dahlmann M, Stein U,  Relógio A. Core-Clock Genes Regulate Proliferation and Invasion via a Reciprocal Interplay with MACC1 in Colorectal Cancer Cells. Cancers (Basel). 2022 Jul 16; 14(14):3458. doi: 10.3390/cancers14143458. PMID: 35884519; PMCID: PMC9319284.
[5] Kim SM, Jeon Y, Jang JY, Lee H. NR1D1 deficiency in the tumor microenvironment promotes lung tumor development by activating the NLRP3 inflammasome. Cell Death Discov. 2023 Jul 31; 9(1):278. doi: 10.1038/s41420-023-01554-3. PMID: 37524704; PMCID: PMC10390518.
[6] Yang Y, Bai Y, Wang X, Guo Y, Yu Z, Feng D, Zhang F, Li D, Han P. Clock gene NR1D1 might be a novel target for the treatment of bladder cancer. Urol Oncol. 2023 Jul; 41(7):327.e9-327.e18. doi: 10.1016/j.urolonc.2023.04.021. Epub 2023 May 18. PMID: 37208228.
[7] Wang H, Fu Y. NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway. BMC Cancer. 2021 Jul 30; 21(1):871. doi: 10.1186/s12885-021-08597-8. PMID: 34330232; PMCID: PMC8323274.

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