The Research Progress of Gut-Brain-Microbiome Axis in the Pathogenesis of Alzheimer's Disease

Zhiqiang Hao; Huiwen Yang; Feng Miao

doi:10.23977/medsc.2024.050420

The Research Progress of Gut-Brain-Microbiome Axis in the Pathogenesis of Alzheimer's Disease

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DOI: 10.23977/medsc.2024.050420 | Downloads: 18 | Views: 919

Author(s)

Zhiqiang Hao ¹, Huiwen Yang ¹, Feng Miao ¹

Affiliation(s)

¹ Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

Corresponding Author

Feng Miao

ABSTRACT

Alzheimer's disease (AD) is primarily caused by the pathological changes of tau induced by amyloid-beta (Aβ), which leads to a group of clinical syndromes characterized by cognitive impairment. In recent years, people have gradually realized the complex influence of the gut microbiome on the central nervous system (CNS), and the bidirectional communication between them plays a crucial role, which indicates that the gut microbiome may shape neural development, regulate neurotransmission, and affect behavior, making it a potentially operable target for improving neurodegenerative diseases. Therefore, this paper aims to discuss the molecular mechanisms of the microbiome-gut-brain axis on AD, summarize the new targets and methods of treating AD through the gut microbiome, with the hope of providing new theoretical basis for clinical treatment of AD.

KEYWORDS

Alzheimer's disease; Microbiota–gut–brain axis; Microglia; Review

CITE THIS PAPER

Zhiqiang Hao, Huiwen Yang, Feng Miao, The Research Progress of Gut-Brain-Microbiome Axis in the Pathogenesis of Alzheimer's Disease. MEDS Clinical Medicine (2024) Vol. 5: 153-159. DOI: http://dx.doi.org/10.23977/medsc.2024.050420.

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The Research Progress of Gut-Brain-Microbiome Axis in the Pathogenesis of Alzheimer's Disease

Author(s)

Affiliation(s)

Corresponding Author

ABSTRACT

KEYWORDS

CITE THIS PAPER

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