Author(s)

Ge Li ¹, Chenqi Li ², Yaoyao Wang ², Fuyu Yao ², Xue Bai ²

Affiliation(s)

¹ Respiratory Department, Guang'anmen Hospital (Baoding), China Academy of Chinese Medical Sciences, Baoding, Hebei, 071000, China
² Guang'anmen Hospital (Baoding), China Academy of Chinese Medical Sciences, Baoding, Hebei, 071000, China

Corresponding Author

Ge Li

ABSTRACT

The purpose of this investigation is to assess the therapeutic effectiveness of the "Jinshui Liujun" concoction, with adjustments, in the management of sudden deteriorations in chronic obstructive pulmonary disease (COPD) (characterized by phlegm and blood stagnation blocking the lungs, and a deficiency of qi in the lungs and kidneys) using a randomized controlled trial methodology. The research incorporated 100 individuals identified with acute exacerbations of COPD and categorized as having phlegm and blood stagnation obstructing the lungs, and a deficiency of qi in the lungs and kidneys according to traditional Chinese medicine (TCM). They were arbitrarily partitioned into a treatment cohort (50 instances, receiving "Jinshui Liujun" concoction with alterations) and a control group (50 instances, receiving standard Western medicinal treatment). Participants in the treatment group ingested a daily dosage of "Jinshui Liujun" concoction for a duration of 4 weeks; The control group was administered with a combination of Salmeterol and Fluticasone via inhalation. Primary outcome measures encompass clinical effectiveness, pulmonary function indices (FEV1, FEV1/FVC) and blood gas analysis indices (PaCO2, PaO2). The findings revealed that the overall efficacy rate of the treatment group was 86.0%, which was noticeably higher than that of the control group (70.0%, P < 0.05). The enhancement in FEV1 and FEV1/FVC within the treatment group was more pronounced than that within the control group (P<0.05), and the treatment group also exhibited a more significant improvement in reducing PaCO2 and increasing PaO2 (P<0.05). With regard to safety, the occurrence of adverse reactions in the treatment group was merely 6%, which is considerably lower than the 14% in the control group, and all were minor symptoms that swiftly dissipated. This research indicates that the "Jinshui Liujun" concoction, with adjustments, exhibits substantial clinical effectiveness in the treatment of acute exacerbations of COPD (characterized by phlegm and blood stagnation blocking the lungs, and a deficiency of qi in the lungs and kidneys), effectively ameliorating patients' clinical symptoms, pulmonary function, and blood gas analysis indices, with high safety. This offers novel scientific evidence for the treatment of COPD with TCM and implies that the "Jinshui Liujun" concoction, with modifications, possesses potential application value in the treatment of COPD.

KEYWORDS

"Jinshui Liujun" decoction; acute exacerbation; chronic obstructive pulmonary disease; randomized controlled trial; Therapeutic effect

CITE THIS PAPER

Ge Li, Chenqi Li, Yaoyao Wang, Fuyu Yao, Xue Bai, Therapeutic effect of "Jinshui Liujun" in acute exacerbation of chronic obstructive pulmonary disease: A randomized controlled trial. MEDS Chinese Medicine (2024) Vol. 6: 42-48. DOI: http://dx.doi.org/10.23977/medcm.2024.060406.

REFERENCES

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