Author(s)

Xinhua Cheng ¹, Lei Zhang ¹

Affiliation(s)

¹ Department of Orthopaedics, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China

Corresponding Author

Lei Zhang

ABSTRACT

In response to the challenges of insufficient bone healing speed and prevention of complications in the repair of large-scale bone defects, this paper explores the clinical application of this combined technique in large-scale bone defect repair and its impact on bone healing, aiming to evaluate its potential in promoting bone healing and reducing complications. This study selects 30 patients with extensive bone defects, all of whom meet the inclusion criteria. Firstly, all patients undergo standardized imaging examinations and basic assessments before surgery to ensure that the site and extent of bone defects met the surgical conditions. Then, a membrane induction technique is used to cover the defect area, forming a physical barrier that prevents non-bone cells from the surrounding tissue from entering the bone repair area. At the same time, the platelet-enriched part of the patient is used to prepare platelet-rich gel through centrifugation technology, which is applied to the bone defect site to enhance the concentration of local growth factors and promote the proliferation and differentiation of bone cells. Finally, all patients undergo regular radiographic and clinical follow-up after surgery to evaluate bone healing and monitor the occurrence of complications. Data collection includes bone healing progress, clinical symptoms, incidence of complications, and patient quality of life scores. The membrane combined with platelet-rich gel strategy is significantly ahead in multiple core efficacy indicators. This combination therapy shortens the healing period to 12 weeks, which is better than the 16 weeks of the traditional regimen and the 18 weeks of the control group. The complication rate in the membrane + platelet-rich gel group is as low as 5%, which is significantly better than the 15% of the traditional repair group and the 20% of the control group. The treatment method in this paper provides a new and effective treatment option for orthopedic clinics and has good application prospects.

KEYWORDS

Membrane Induction Technology Combined With Platelet-Rich Gel, Large-Scale Bone Defect Repair, Clinical Effect, Related Complications

CITE THIS PAPER

Xinhua Cheng, Lei Zhang. Clinical Effect of Membrane Induction Technology Combined with Platelet-Rich Gel in Repairing Large-Scale Bone Defects. MEDS Clinical Medicine (2024) Vol. 5: 128-136. DOI: http://dx.doi.org/10.23977/medsc.2024.050518.

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