Author(s)

Xiaohua Wu ¹, Qian Guo ¹, Chan Zhao ²

Affiliation(s)

¹ First Clinical School of Medicine, Shaanxi University of Chinese Medicine, Xianyang, China
² Department of Dermatology, Baoji Hospital of Traditional Chinese Medicine Affiliated with Shaanxi University of Chinese Medicine, Baoji, China

Corresponding Author

Chan Zhao

ABSTRACT

ASCC lacks specific clinical and imaging features, its clinical presentation is similar to that of other skin cancers such as basal cell carcinoma and preoperative diagnosis is difficult. The diagnosis depends on postoperative histopathological examination, often supplemented by immunohistochemistry. Surgical resection is the main treatment, but the prognosis is controversial. It accounts for about 4. 9% of all squamous cell carcinoma cases. It is more common in the elderly, and males have a significantly higher incidence rate than females. It mainly occurs in the head and neck and other exposed sites. ASCC in the vulva is rare, but it is highly aggressive, with a high risk of metastasis and poor prognosis. This article reports a case of vulva. A 54-year-old man with ASCC was reported. By analyzing the clinical features, pathogenesis, etiology, differential diagnosis, treatment and prognosis of ASCC, we aimed to provide reference for clinical management.

KEYWORDS

Acantholytic squamous cell carcinoma of the vulva, MOS surgery, case report

CITE THIS PAPER

Xiaohua Wu, Qian Guo, Chan Zhao. A case of male vulvar acantholytic squamous cell Carcinoma. MEDS Clinical Medicine (2025) Vol. 6: 81-85. DOI: http://dx.doi.org/10.23977/medsc.2025.060112.

REFERENCES

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[5] Lasser, A., Cornog, J. L., & Morris, J. M. (1974). Adenoid squamous cell carcinoma of the vulva. Cancer, 33(1), 224–227. https://doi. org/10. 1002/1097-0142(197401)33:1<224::aid-cncr2820330133>3. 0. co;2-6. 
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[7] Ogawa, T., Kiuru, M., Konia, T. H., & Fung, M. A. (2017). Acantholytic squamous cell carcinoma is usually associated with hair follicles, not acantholytic actinic keratosis, and is not "high risk": Diagnosis, management, and clinical outcomes in a series of 115 cases. Journal of the American Academy of Dermatology, 76(2), 327–333. https://doi.org/10.1016/j. jaad. 2016. 09. 024.

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