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Analysis of postoperative pulmonary infection and its risk factors in patients with esophageal cancer treated with thoracoscopic McKeown and thoracotomy

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DOI: 10.23977/medsc.2025.060114 | Downloads: 11 | Views: 367

Author(s)

Peirui Chen 1, Zheng Qin 1, Jing Lv 1, Mingqiang Diao 1

Affiliation(s)

1 Department of Cardiothoracic Surgery, People's Hospital of Deyang City, Deyang, Sichuan, China

Corresponding Author

Peirui Chen

ABSTRACT

This study aims to compare the incidence of postoperative pulmonary infections between thoracoscopic McKeown esophagectomy and open thoracotomy for esophageal cancer, and to identify risk factors associated with this complication. A retrospective analysis was conducted on the clinical data of 89 patients with esophageal cancer who underwent surgical treatment. Among them, 45 patients received McKeown's method via thoracoscope (laparoscopic group), and 44 patients received open chest surgery (open chest surgery group). The incidence of postoperative pulmonary infection and the levels of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), red blood cell immune complex ring rate (RBC-ICR), and red blood cell adherence to tumor cell ring rate (TRR) were compared between the two groups. Logistic regression analysis was used to analyze the risk factors influencing postoperative pulmonary infection. Compared with total endoscopic surgery, thoracic surgery for esophageal cancer is more likely to cause pulmonary infection. Age, operation time, thoracotomy, diabetes mellitus and the level of NLR, PLR and TRR 2 days after surgery may be the risk factors for postoperative pulmonary infection.

KEYWORDS

Esophageal cancer; Lung infection; Total endoscopic surgery; Open-heart surgery; Influencing factor

CITE THIS PAPER

Peirui Chen, Zheng Qin, Jing Lv, Mingqiang Diao. Analysis of postoperative pulmonary infection and its risk factors in patients with esophageal cancer treated with thoracoscopic McKeown and thoracotomy. MEDS Clinical Medicine (2025) Vol. 6: 93-98. DOI: http://dx.doi.org/10.23977/medsc.2025.060114.

REFERENCES

[1] CAO W, CHEN H D, YU Y W, et al. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020 [J]. Chin Med J, 2021, 134(7): 783-791.  
[2] ARUN J S, BINGENER J. Diagnostic transgastric endoscopic peritoneoscopy for staging of pancreatic and esophageal cancer [J]. Minerva Chirurgica, 2012, 67(2): 127-140. 
[3] PETROPOULOS K, MACHERAS A, LIAKAKOS T, et al. Minimally invasive esophagectomy for esophageal cancer: techniques and outcomes [J]. Chirurgia (Bucharest, Romania : 1990), 2015, 110(2): 99-108. 
[4] BREMNER R M, DEMEESTER T R. Surgical treatment of esophageal carcinoma [J]. Gastroenterology clinics of North America, 1991, 20(4): 743-763. 
[5] KATO H. Surgical treatment of esophageal varices [J]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1992, 67(6): 757-760. 
[6] VAN WORKUM F, SLAMAN A E, HENEGOUWEN M I V, et al. Propensity Score-Matched Analysis Comparing Minimally Invasive Ivor Lewis Versus Minimally Invasive Mckeown Esophagectomy [J]. Ann Surg, 2020, 271(1): 128-133. 
[7] VAN WORKUM F, BERKELMANS G H, KLARENBEEK B R, et al. McKeown or Ivor Lewis totally minimally invasive esophagectomy for cancer of the esophagus and gastroesophageal junction: systematic review and meta-analysis [J]. J Thorac Dis, 2017, 9: S826-S833. 
[8] XING H J, HU M Y, WANG Z Q, et al. Short-term outcomes of Ivor Lewis vs. McKeown esophagectomy: A meta-analysis [J]. Frontiers in Surgery, 2022, 9. 
[9] WANG J P, HU J F, ZHU D Y, et al. McKeown or Ivor Lewis minimally invasive esophagectomy: a systematic review and meta-analysis [J]. Translational Cancer Research, 2020, 9(3): 1518. 
[10] DRöGE W. Free radicals in the physiological control of cell function [J]. Physiol Rev, 2002, 82(1): 47-95. 
[11] CHEN S, LU D C, WANG W, et al. Plasma metabolomic profiling of repeated restraint stress in rats [J]. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2020, 1160. 
[12] QING H, DESROULEAUX R, ISRANI-WINGER K, et al. Origin and Function of Stress-Induced IL-6 in Murine Models [J]. Cell, 2020, 182(2): 372. 
[13] KHAN A R, GEIGER L, WIBORG O, et al. Stress-Induced Morphological, Cellular and Molecular Changes in the Brain-Lessons Learned from the Chronic Mild Stress Model of Depression [J]. Cells, 2020, 9(4). 
[14] RINALDI A, VINCENTI S, DE VITO F, et al. Stress induces region specific alterations in microRNAs expression in mice [J]. Behavioural Brain Research, 2010, 208(1): 265-269. 
[15] HIGUCHI F, UCHIDA S, YAMAGATA H, et al. Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice [J]. Journal of Neuroscience, 2016, 36(27): 7253-7267. 
[16] LONER R A. Lessons learned about stress and the heart after major earthquakes [J]. American Heart Journal, 2019, 215: 20-26.
[17] Zhu ZJ, Zhao YF, Chen LQ, et al. Clinical application of layered anastomosis during esophagogastrostomy. World J Surg.2008;32:583-588.
[18] LI J, FAN J G. Characteristics and Mechanism of Liver Injury in 2019 Coronavirus Disease [J]. Journal of Clinical and Translational Hepatology, 2020, 8(1): 13-17. 
[19] QUíLEZ M E, LóPEZ-AGUILAR J, BLANCH L. Organ crosstalk during acute lung injury, acute respiratory distress syndrome, and mechanical ventilation [J]. Current Opinion in Critical Care, 2012, 18(1): 23-28.

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