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  4. Vol 6, Issue 2, 2025

Correlation study of geriatric frailty syndrome with ultrasound elastography parameters

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DOI: 10.23977/medsc.2025.060212 | Downloads: 11 | Views: 342

Author(s)

Xuan Zhou 1, Min Kou 1, Jie Wan 1

Affiliation(s)

1 Department of Ultrasound Diagnostic, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, China

Corresponding Author

Jie Wan

ABSTRACT

This study examines the changes in renal and carotid artery elasticity parameters in patients with geriatric frailty syndrome, analyzing the clinical value of ultrasound elastography (UE) in frailty assessment. A total of 120 elderly frail patients (frailty group) and 60 healthy elderly individuals (control group) were selected from January 2023 to December 2024. The Fried frailty phenotype criteria were used for frailty staging, and shear wave elastography (SWE) was applied to measure the elastic modulus values of renal cortex and carotid arteries. Traditional biochemical indicators (blood creatinine, eGFR) and atherosclerosis parameters (pulse wave velocity, PWV) were also recorded simultaneously. Pearson correlation analysis and ROC curve evaluation were used to assess the relationship between elasticity parameters and frailty severity. The results showed that the renal cortex elasticity value (28.5±5.2 kPa) and carotid artery elasticity value (35.6±6.8 kPa) in the frailty group were significantly higher than those in the control group (12.8±2.1 kPa, 18.3±3.4 kPa). Elasticity values were positively correlated with the frailty index (FI) (p<0.01) and negatively correlated with eGFR (p<0.01). ROC curve analysis revealed that the combined use of renal cortex elasticity value and carotid artery elasticity value had an AUC of 0.93 for diagnosing moderate to severe frailty (sensitivity 88%, specificity 85%). The study found that ultrasound elastography parameters are significantly associated with the severity of geriatric frailty syndrome and can serve as a non-invasive, objective assessment tool to assist in early identification and intervention of frailty status.

KEYWORDS

Senile Frailty Syndrome; Ultrasound Elastography; Shear Wave Elastography; Pulse Wave Conduction Velocity; Frailty Index

CITE THIS PAPER

Xuan Zhou, Min Kou, Jie Wan, Correlation study of geriatric frailty syndrome with ultrasound elastography parameters. MEDS Clinical Medicine (2025) Vol. 6: 82-86. DOI: http://dx.doi.org/10.23977/medsc.2025.060212.

REFERENCES

[1] Geriatric Medicine Branch, Chinese Medical Association, Hao Qiukui, Li Jun, etc. Chinese expert consensus on frailty assessment and prevention among elderly patients [J]. Chinese Journal of Geriatrics, 2017,36 (3): 251-256.
[2] Li X, Zhao Y, Chen X, et al. Shear-wave elastography for the evaluation of liver fibrosis in elderly patients with chronic liver disease: a meta - analysis[J]. Ultrasound Med Biol, 2022, 48(11): 2431 - 2443.
[3] Liu X, Zhang Y, Chen Y, et al. Application of renal shear - wave elastography in the assessment of renal function decline in the elderly[J]. Clin Hemorheol Microcirc, 2020, 74(2): 217 - 226.

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