Author(s)

Hu Yue ^1,2, Duan Lihua ³

Affiliation(s)

¹ Nanchang University, Nanchang, Jiangxi, China
² Jiujiang First People's Hospital, Jiujiang, Jiangxi, China
³ Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, China

Corresponding Author

Hu Yue

ABSTRACT

This study aims to elucidate the characteristics of bone metabolic imbalance and its clinical significance as reflected by the changes in serum PINP and β-CTX levels before and after glucocorticoid therapy in patients with systemic lupus erythematosus (SLE). The results indicate a rapid decline in PINP levels during the early phase of treatment, suggesting a marked suppression of bone formation, while β-CTX levels, though showing delayed elevation in some cases, remained indicative of active bone resorption overall, demonstrating that a bidirectional imbalance in bone metabolism had already developed as a systemic stress response in the short term. Analysis of these biomarkers contributes to the establishment of individualized bone health monitoring models for SLE patients, providing an evidence-based foundation for risk management during glucocorticoid therapy.

KEYWORDS

Systemic Lupus Erythematosus; Glucocorticoids; PINP; β-CTX

CITE THIS PAPER

Hu Yue, Duan Lihua, Changes in Serum PINP and β-CTX Levels before and after Glucocorticoid Therapy in Patients with Systemic Lupus Erythematosus and Their Clinical Significance. MEDS Public Health and Preventive Medicine (2025) Vol. 5: 128-132. DOI: http://dx.doi.org/10.23977/phpm.2025.050119.

REFERENCES

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[2] Katechis S , Pitsigavdaki S , Nikoloudaki M , et al. Combination of clinical factors predicts successful glucocorticoid withdrawal in systemic lupus erythematosus (SLE): results from a multicentre, retrospective cohort study.[J].RMD open,2025,11(1):
[3] Irastorza R G ,Ruiz P D ,Bartolome D L , et al. No Effect of Low-Dose Glucocorticoid Maintenance Therapy on Damage in SLE Patients in Prolonged Remission: A Propensity Score Analysis of the Longitudinal Lupus-Cruces-Bordeaux Inception Cohort[J].Journal of Clinical Medicine,2024,13(20):6049-6049.
[4] Katz P ,Pedro S ,Park J , et al.EPH179 Patterns of Glucocorticoid Use Among Persons with Systemic Lupus Erythematosus (SLE) over Fifteen Years[J].Value in Health,2024,27(6S):S185.
[5] Iglesias M D ,Ruiz P D ,Irastorza R G .Use of Glucocorticoids in SLE: A Clinical Approach.[J].Mediterranean journal of rheumatology,2024,35(Suppl 2):342-353.

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