Author(s)

Lu Xin ¹, Chen Ping ¹, Zhang Xiaojuan ¹, Guo Qian ¹, Dong Pan ¹

Affiliation(s)

¹ Chongqing University Affiliated Cancer Hospital, Chongqing, 400000, China

Corresponding Author

Chen Ping

ABSTRACT

Spinal metastases are among the most common complications of advanced malignant tumors, significantly affecting patients' neurological function, quality of life, and survival time. This paper systematically outlines the epidemiological characteristics, pathophysiological mechanisms, and clinical manifestations of spinal metastases, with a particular focus on multidisciplinary comprehensive management strategies. These strategies include conservative treatment, surgical intervention, radiotherapy, targeted and immunotherapy, as well as rehabilitation and psychological support. The importance of individualized treatment and multidisciplinary collaboration in improving patient outcomes is emphasized, providing a systematic reference for clinical management.

KEYWORDS

Spinal Metastases; Comprehensive Management Strategy; Progress

CITE THIS PAPER

Lu Xin, Chen Ping, Zhang Xiaojuan, Guo Qian, Dong Pan, Research Progress on Comprehensive Management Strategies for Patients with Spinal Metastases. MEDS Clinical Medicine (2025) Vol. 6: 74-78. DOI: http://dx.doi.org/10.23977/medsc.2025.060311.

REFERENCES

[1] Elsamadicy A A , Havlik J , Reeves B C ,et al. Association of Malnutrition with Surgical and Hospital Outcomes after Spine Surgery for Spinal Metastases: A National Surgical Quality Improvement Program Study of 1613 Patients[J].Journal of Clinical Medicine, 2024, 13(6):15.DOI:10.3390/jcm13061542.
[2] Song C , Zhang W , Luo C ,et al. Prognostic factors for surgical site infection in patients with spinal metastases and following surgical treatment[J].Medicine, 2024, 103(11):e37503-59.DOI:10.1097/MD.0000000000037503.
[3] Menta A K , Weber-Levine C , Jiang K ,et al. Robotic assisted surgery for the treatment of spinal metastases: A case series[J].Clinical neurology and neurosurgery, 2024, 243(000):7.DOI:10.1016/j.clineuro.2024.108393.
[4] Engineering J O H .Retracted: Expression of CX3CL1 and CCL28 in Spinal Metastases of Lung Adenocarcinoma and Their Correlation with Clinical Features and Prognosis[J].Journal of Healthcare Engineering, 2023, 2023(000): 1. DOI:10.1155/2023/9812681.
[5] Zileli M , Zygourakis C , Niu T ,et al. Surgical options for metastatic spine tumors: WFNS spine committee recommendations[J].Neurosurgical Review, 2024, 47(1):1-30.DOI:10.1007/s10143-024-02949-1.
[6] Khalid S I , Massaad E , Kiapour A ,et al. Machine learning–based detection of sarcopenic obesity and association with adverse outcomes in patients undergoing surgical treatment for spinal metastases: Presented at the 2023 AANS/CNS Joint Section on Disorders of the Spine and Peripheral Nerves[J].Journal of Neurosurgery: Spine, 2024, 40(3):10.DOI:10.3171/2023.9.SPINE23864.
[7] Husain S , Malhotra A K , Badhiwala J H ,et al. Contemporary trends in the incidence and timing of spinal metastases: A population-based study[J].Neuro-Oncology Advances, 2024(1):1.DOI:10.1093ajnldae051.
[8] Prandzhev V S , Vezirska D I .Multi-level Percutaneous Vertebroplasty for Multiple Spinal Metastases With Asymptomatic Epidural Compression: A Case-Based Example of Minimally Invasive Patient Management[J]. Cureus, 2024.DOI:10.7759/cureus.72102.
[9] Jaoude J A , Chuang C F , Klebaner D ,et al. Repeat Stereotactic Radiosurgery in Patients with Spinal Metastases Recurrent Following Initial Radiosurgery[J].International Journal of Radiation Oncology, Biology, Physics, 2024, 120(2-Sup).DOI:10.1016/j.ijrobp.2024.07.481.
[10] Mckibben N S , Macconnell A E , Chen Y ,et al. Risk Factors for Radiotherapy Failure in the Treatment of Spinal Metastases[J].Global Spine Journal, 2025, 15(2).DOI:10.1177/21925682231213290.

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