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  4. Vol 6, Issue 1, 2025

Correlation of Coronary Heart Disease Mortality with HALP Score: A Cross-Sectional Study Based on NHANES

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DOI: 10.23977/socmhm.2025.060117 | Downloads: 6 | Views: 270

Author(s)

Ji Ouyang 1, Mengjiao Li 2, Jiayuan Song 3, Zhixi Hu 1

Affiliation(s)

1 College of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine, Changsha, China
2 The Second of Clinical Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310053, Zhejiang, China
3 College of Integrative Medicine, Changchun University of Chinese Medicine, 130117, Changchun, China

Corresponding Author

Zhixi Hu

ABSTRACT

This study investigates the association between HALP score (hemoglobin, albumin, lymphocytes, platelets) and all-cause mortality in coronary heart disease (CHD) patients using NHANES data (1998-2018). Eligible CHD patients were grouped into Q1-Q4 by HALP quartiles. Analyses included weighted Cox models, restricted cubic spline (RCS) regression, Kaplan-Meier (K-M) curves, and subgroup analyses. Results showed 937 all-cause deaths. After covariate adjustment, Q2-Q4 had lower mortality risk (HR=0.74, 0.68, 0.70; 95% CIs respectively). A significant J-shaped nonlinear relationship was found (nonlinear P<0.001) with a turning point at 78.02: each 1-unit increase in HALP ≤78.02 reduced death risk by 1.3% (HR=0.987), while the protective effect plateaued above this. K-M curves showed higher HALP correlated with higher survival, and subgroup analyses confirmed robustness. The HALP score exhibits a J-shaped relationship with all-cause mortality in patients with coronary heart disease (CHD) and has potential prognostic value.

KEYWORDS

Coronary Heart Disease; HALP; All-Cause Mortality; NHANES

CITE THIS PAPER

Ji Ouyang, Mengjiao Li, Jiayuan Song, Zhixi Hu, Correlation of Coronary Heart Disease Mortality with HALP Score: A Cross-Sectional Study Based on NHANES. Social Medicine and Health Management (2025) Vol. 6: 131-145. DOI: http://dx.doi.org/10.23977/socmhm.2025.060117.

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