Author(s)

Yaohui Wang ¹

Affiliation(s)

¹ Department of Internal Medicine, Foshan Women and Children's Hospital, Foshan, Guangdong, China

Corresponding Author

ABSTRACT

This study aimed to validate the triglyceride glucose-body mass index (TyG-BMI) as a predictor of ultrasonography-confirmed non-alcoholic fatty liver disease (NAFLD) in hospitalized patients with type 2 diabetes mellitus (T2DM). In this retrospective cohort analysis of 76 T2DM patients, NAFLD was diagnosed using standardized abdominal ultrasonography. Multivariate logistic regression adjusted for age and sex revealed that patients with NAFLD exhibited significantly higher TyG-BMI levels than non-NAFLD controls (p<0.05). Each 10-unit increment in TyG-BMI increased NAFLD risk by 30% (adjusted OR=1.3, 95% CI: 1.1–1.6, p<0.05). Notably, the highest TyG-BMI tertile demonstrated an 18.3-fold elevated risk of NAFLD compared to the lowest tertile (adjusted OR=18.3, 95% CI: 3.1–107.7, p<0.05). These findings establish TyG-BMI as a robust predictor of NAFLD in T2DM, with extreme risk elevation in high-index patients. Integration of TyG-BMI into diabetes management protocols may enable early risk stratification and targeted interventions.

KEYWORDS

CITE THIS PAPER

Yaohui Wang, TyG-BMI Index as a Potential Predictor of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus. MEDS Clinical Medicine (2025) Vol. 6: 19-22. DOI: http://dx.doi.org/10.23977/medsc.2025.060404.

REFERENCES

[1] LI N, TAN H, XIE A, et al. Value of the triglyceride glucose index combined with body mass index in identifying non-alcoholic fatty liver disease in patients with type 2 diabetes [J]. BMC endocrine disorders, 2022, 22(1): 101.
[2] WANG X, LIU J, CHENG Z, et al. Triglyceride glucose-body mass index and the risk of diabetes: a general population-based cohort study [J]. Lipids in health and disease, 2021, 20(1): 99.
[3] CASTERA L, FRIEDRICH-RUST M, LOOMBA R. Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease [J]. Gastroenterology, 2019, 156(5): 1264-81.e4.
[4] WANG W, ZHOU F, LI Y, et al. U-shaped association between triglyceride glucose-body mass index with all-cause and cardiovascular mortality in US adults with osteoarthritis: evidence from NHANES 1999-2020 [J]. Scientific reports, 2024, 14(1): 19959.
[5] BI T. Relationship between thyroid hormone levels and metabolic dysfunction associated steatotic liver disease in patients with type 2 diabetes: A clinical study [J]. Medicine, 2024, 103(26): e38643.
[6] Ramandi A, George J, Merat S, et al. Polypill protects MAFLD patients from cardiovascular events and mortality: a prospective trial [J]. Hepatology international, 2023, 17(4): 882-888.
[7] POSTIC C, GIRARD J. The role of the lipogenic pathway in the development of hepatic steatosis [J]. Diabetes & metabolism, 2008, 34(6 Pt 2): 643-648.
[8] MO M, HUANG Z, LIANG Y, et al. The safety and efficacy evaluation of sodium-glucose co-transporter 2 inhibitors for patients with non-alcoholic fatty liver disease: An updated meta-analysis [J]. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2022, 54(4): 461-468.
[9] Simental-Mendía L E, Rodríguez-Morán M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects [J]. Metabolic syndrome and related disorders, 2008, 6(4): 299-304.
[10] Yilmaz B, Koklu S, Buyukbayram H, et al. Chronic hepatitis B associated with hepatic steatosis, insulin resistance, necroinflammation and fibrosis [J]. African health sciences, 2015, 15(3): 714-718.
[11] Fabbrini E, Magkos F, Mohammed B S, et al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity [J]. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(36): 15430-15435.
[12] Yang Z, Yu B, Wang Z, et al. Comparison of the prognostic value of a comprehensive set of predictors in identifying risk of metabolic-associated fatty liver disease among employed adults [J]. BMC public health, 2023, 23(1): 584.
[13] Cho Y K, Kim H S, Park J Y, et al. Triglyceride-Glucose Index Predicts Cardiovascular Outcome in Metabolically Unhealthy Obese Population: A Nationwide Population-Based Cohort Study [J]. Journal of obesity & metabolic syndrome, 2022, 31(2): 178-186.

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