Author(s)

Naizhuang Jake Wang ¹, Doris Dai ¹, Amelia ¹, Mok Wai Fun ¹

Affiliation(s)

¹ Biowell R&D Center, Eternal Grace PTE.LTD, 2 Venture Drive, #08-31 Vision Exchange, Singapore, 608526

Corresponding Author

Doris Dai

ABSTRACT

This study investigated the pharmacokinetic profile of L-ergothioneine (EGT) delivered via a liquid nanoemulsion versus a conventional powder formulation in rats. Plasma concentrations were monitored over a 24-hour period following oral administration of equal doses (20 mg/kg). The nanoemulsion group demonstrated significantly accelerated absorption, with plasma levels at 0.5 h and 1 h reaching 2.51- and 3.70-fold higher, respectively, than those of the powder group. The nanoemulsion achieved its peak concentration (Cₘₐₓ = 400.3 ng/mL) at 2 h (Tₘₐₓ), whereas the powder formulation reached a lower Cₘₐₓ (300.7 ng/mL) at a later Tₘₐₓ of 4 h. After 4 h, the concentration-time profiles of both groups converged, indicating that the nanoemulsion primarily enhances the absorption rate without altering overall bioavailability (AUC). These findings confirm that nanoemulsion delivery significantly improves the early systemic exposure of EGT.

KEYWORDS

L-Ergothioneine (EGT), OCTN1 (SLC22A4) Transporter, Oral Bioavailability, Absorption Rate, Pharmacokinetics (Cmax, Tmax)

CITE THIS PAPER

Naizhuang Jake Wang, Doris Dai, Amelia, Mok Wai Fun, Liquid Nanoemulsion Delivery: A Technology for Accelerating the Early Systemic Availability of L-Ergothioneine in Rats. Advances in Industrial Pharmacy and Pharmaceutical Sciences (2025) Vol. 3: 1-5. DOI: http://dx.doi.org/10.23977/aipps.2025.030101.

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