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  4. Vol 5, Issue 3, 2025

Case Report and Analysis of Herpesviral Encephalitis with MOG Antibody-Associated Autoimmune Encephalitis in Children

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DOI: 10.23977/phpm.2025.050302 | Downloads: 1 | Views: 38

Author(s)

Li Jin 1,2, Sumin Sui 1,2, Jing Bai 2

Affiliation(s)

1 Bengbu Medical University, Graduate School, 233030, Bengbu, Anhui, China
2 Bozhou People's Hospital, Bozhou, Anhui, 236805, China

Corresponding Author

Sumin Sui

ABSTRACT

This article reports a case of herpes viral encephalitis complicated with MOG antibody-associated autoimmune encephalitis in a child, detailing its clinical manifestations, diagnostic process, treatment measures, and prognosis. The patient presented with fever, bilateral lower limb weakness, and restlessness. Cerebrospinal fluid analysis confirmed the presence of herpes virus (human herpesvirus 7, HHV-7), while MOG antibody testing was positive. Imaging studies revealed multifocal cerebral lesions. After antiviral therapy, immunomodulatory treatment, and symptomatic supportive care, the patient's condition gradually improved, though long-term follow-up remains necessary. This case underscores the importance of early diagnosis and comprehensive management in such complex conditions, providing valuable clinical insights for physicians.

KEYWORDS

Children; Viral Encephalitis; MOG Antibody; Autoimmune Encephalitis; Diagnosis and Treatment Analysis

CITE THIS PAPER

Li Jin, Sumin Sui, Jing Bai, Case Report and Analysis of Herpesviral Encephalitis with MOG Antibody-Associated Autoimmune Encephalitis in Children. MEDS Public Health and Preventive Medicine (2025) Vol. 5: 8-12. DOI: http://dx.doi.org/10.23977/phpm.2025.050302.

REFERENCES

[1] Chi Bowen, Wang Jiawei. Research Advances on Autoimmune Encephalitis Following Herpes Simplex Virus Infection [J]. Journal of Capital Medical University, 2021,42(03):341-346.
[2] Yan Shuang, Wu Miaojuan, Sun Dan. Clinical Characteristics Analysis of 14 Cases of Post-herpetic Encephalitis Epilepsy in Children [J]. China Journal of Practical Pediatrics, 2024,39(07):518-523.
[3] LIU Y T, JIH J, DAI X,et al. Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome[J]. Nature, 2019, 570(7760):257-261.
[4] Zhang Feng, Gao Liying, Song Xue, et al. Establishment and Application of a Real-Time Quantitative PCR Method for Simultaneous Detection of Human Herpesviruses 6 and 7 Nucleic Acids [J]. Journal of Pharmaceutical Analysis, 2021, 41(09):1565-1575.
[5] Wu Xiaofang, Lu Jun, Hu Shaoyan, et al. Two Cases of HHV-7 Viral Encephalitis Following Pediatric Hematopoietic Stem Cell Transplantation [J]. China Journal of Pediatrics Hematology and Oncology, 2022, 27(06): 410-412.
[6] Ward KN. The natural history and laboratory diagnosis of human herpesviruses-6 and -7 infections in the immunocompetent. J Clin Virol. 2005;32(3):183-193.
[7] Huang LM, Lee CY, Liu MY, Lee PI. Primary infections of human herpesvirus-7 and herpesvirus-6: a comparative, longitudinal study up to 6 years of age. Acta Paediatr. 1997;86(6):604-608.
[8] Sechi, Elia et al. "Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD): A Review of Clinical and MRI Features, Diagnosis, and Management." Frontiers in neurology vol. 13 885218. 17 Jun. 2022, doi:10. 3389/fneur. 2022.885218.
[9] Hacohen Y, Absoud M, Deiva K, et al. Myelin oligodendrocyte glycoprotein antibodies are associated with a non-MS  course in children[J]. Neurol Neuroimmunol Neuroinflamm, 2015,2(2):e81.
[10] Zheng J, Chen F, Wu K, et al. Clinical and virological impact of single and dual infections with influenza A  (H1N1) and SARS-CoV-2 in adult inpatients[J]. PLoS Negl Trop Dis, 2021,15(11):e9997.
[11] Boronczyk M, Wegrzynek J, Boronczyk A, et al. The MOG antibody associated encephalitis preceded by COVID-19 infection; a case  study and systematic review of the literature[J]. Front Neurol, 2023,14:1239657.
[12] Feng Yiling and Li Xiujuan. Advances in Research on the Correlation Between Infection and MOGAD [J]. Clinical Medicine Progress, 2024,14(4):1287-1293.
[13] Epstein L G, Shinnar S, Hesdorffer D C, et al. Human herpesvirus 6 and 7 in febrile status epilepticus: the FEBSTAT study[J]. Epilepsia, 2012,53(9):1481-1488.
[14] Corral I, Sainz D L M S, Rodriguez M, et al. Molecular detection of human herpesvirus 7 DNA in cerebrospinal fluid from adult  patients with neurological disorders[J]. J Neurovirol, 2018,24(3):333-338.
[15] Schwartz K L, Richardson S E, Ward K N, et al. Delayed primary HHV-7 infection and neurologic disease[J]. Pediatrics, 2014,133(6):e1541-e1547.
[16] Foiadelli T, Savasta S, Battistone A, et al. Nucleotide variation in Sabin type 3 poliovirus from an Albanian infant with  agammaglobulinemia and vaccine associated poliomyelitis[J]. BMC Infect Dis, 2016,16:277.
[17] Manti S, Licari A, Montagna L, et al. SARS-CoV-2 infection in pediatric population[J]. Acta Biomed, 2020, 91(11-S): e2020003.
[18] Savasta S, Rovida F, Foiadelli T, et al. West-Nile virus encephalitis in an immunocompetent pediatric patient: successful  recovery[J]. Ital J Pediatr, 2018,44(1):140.
[19] Alexopoulos H, Akrivou S, Mastroyanni S, et al. Postherpes simplex encephalitis: a case series of viral-triggered autoimmunity, synaptic autoantibodies and response to therapy[J]. Ther Adv Neurol Disord, 2018,11:1276990346.
[20] Bradshaw M J, Pawate S, Lennon V A, et al. Herpes simplex virus 1 encephalitis associated with voltage-gated calcium channel  autoimmunity[J]. Neurology, 2015,85(24):2176-2177.

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