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  4. Vol 7, Issue 3, 2025

Research Progress of Traditional Chinese Medicine Compound Regulating Intestinal Flora in the Treatment of Rheumatoid Arthritis

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DOI: 10.23977/medcm.2025.070314 | Downloads: 5 | Views: 103

Author(s)

Fu Chunling 1, Jiang Xiaofan 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, China
2 Shaanxi Provincial People's Hospital, Xi'an, China

Corresponding Author

Fu Chunling

ABSTRACT

This review summarizes the research on the treatment of Rheumatoid arthritis (RA) by traditional Chinese medicine compound and its effect on intestinal flora, including fermented traditional Chinese medicine Qushi Chubi Decoction, Huangqi Guizhi Wuwu Decoction, Huangqin Qingre Chubi Capsule and other traditional Chinese medicine compound. The clinical experiment, animal experiment and the combination of clinical experiment and animal experiment were used in the research, combined with 16 SrRNA sequencing, joint index, pathology, inflammatory factor detection and other techniques to explore the effect of traditional Chinese medicine on RA and the effect of intestinal flora. The results showed that Chinese herbal compounds could alleviate the symptoms of RA by regulating intestinal flora (increasing beneficial bacteria such as Lactobacillus and Bifidobacterium, reducing pathogenic bacteria such as Desulfovibrio and Streptococcus), improving intestinal barrier function or regulating inflammatory factors (reducing pro-inflammatory factors such as IL-1β and IL-6, and increasing anti-inflammatory factors such as IL-10), and some Chinese herbal compounds (such as fermented Chinese medicine Qushi Chubi Decoction and Zhijing Powder) showed the advantages of rapid onset, long-lasting efficacy, high safety and delaying the recurrence of joint pain. The effect of combined medication (such as Qilong Fengshi Pill combined with L-leucine) was more significant. In summary, Chinese herbal compound can be used as a new clinical choice for RA treatment by regulating intestinal flora.

KEYWORDS

Traditional Chinese Medicine Compound, Intestinal Flora, RA

CITE THIS PAPER

Fu Chunling, Jiang Xiaofan, Research Progress of Traditional Chinese Medicine Compound Regulating Intestinal Flora in the Treatment of Rheumatoid Arthritis. MEDS Chinese Medicine (2025) Vol. 7: 106-112. DOI: http://dx.doi.org/10.23977/medcm.2025.070314.

REFERENCES

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