The Role of Neutrophil Extracellular Traps in Chronic Airway Inflammatory Diseases and Research Advances

Yang Baoyuan; Wang Qiang; Du Yantao; Ren Kejie

doi:10.23977/medcm.2025.070315

The Role of Neutrophil Extracellular Traps in Chronic Airway Inflammatory Diseases and Research Advances

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DOI: 10.23977/medcm.2025.070315 | Downloads: 2 | Views: 23

Author(s)

Yang Baoyuan ¹, Wang Qiang ², Du Yantao ¹, Ren Kejie ¹

Affiliation(s)

¹ Tianjin University of Traditional Chinese Medicine, Tianjin, China
² Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China

Corresponding Author

Wang Qiang

ABSTRACT

Chronic airway inflammatory diseases are a group of diseases in which inflammation involves the upper and/or lower airways, mainly triggered by infections or immune abnormalities, and common types include asthma and chronic obstructive pulmonary disease. Recent studies have revealed that neutrophil extracellular traps (NETs) play an important role in the pathophysiology of several chronic inflammatory airway diseases. Under normal circumstances, the formation of NETs is beneficial for neutrophils to limit the invasion of pathogens in the body, thereby effectively controlling the range of inflammation and reducing the inflammatory response. However, when NETs are over-formed and their clearance is obstructed, it can cause damage to the airway epithelium, thereby exacerbating the level of airway inflammation. This article elaborates on the overview of NETs, the formation mechanism of NETs, the relationship between NETs and chronic airway inflammatory diseases, and the role and research progress of targeted regulation of NETs in the prevention and treatment of chronic airway inflammatory diseases. The aim is to provide effective reference ideas for the prevention and treatment of chronic airway inflammatory diseases.

KEYWORDS

Neutrophil Extracellular Traps (NETs), Chronic Airway Inflammatory Diseases, Inflammatory Response, Host Immunity, Research Progress

CITE THIS PAPER

Yang Baoyuan, Wang Qiang, Du Yantao, Ren Kejie, The Role of Neutrophil Extracellular Traps in Chronic Airway Inflammatory Diseases and Research Advances. MEDS Chinese Medicine (2025) Vol. 7: 113-122. DOI: http://dx.doi.org/10.23977/medcm.2025.070315.

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The Role of Neutrophil Extracellular Traps in Chronic Airway Inflammatory Diseases and Research Advances

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