Education, Science, Technology, Innovation and Life
Open Access
Sign In

Advances in the Treatment of Uveitis with Traditional Chinese Medicine

Download as PDF

DOI: 10.23977/medcm.2025.070317 | Downloads: 7 | Views: 231

Author(s)

Qing Gao 1,2, Houpan Song 1,2

Affiliation(s)

1 Hunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan Province, China
2 School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan Province, China

Corresponding Author

Houpan Song

ABSTRACT

Uveitis is a prevalent ocular condition that can lead to blindness, commonly affecting young adults and often linked to systemic autoimmune disorders. Contemporary medical treatment primarily involves the use of glucocorticoids, non-steroidal anti-inflammatory drugs, and immunosuppressants. Nevertheless, these treatments are associated with challenges such as high recurrence rates, adverse side effects from prolonged use, and diminished therapeutic effectiveness. In contrast, Traditional Chinese Medicine (TCM) presents distinct advantages in the management of uveitis, including significant alleviation of clinical symptoms, reduction in disease duration, decreased recurrence rates, minimized side effects, and beneficial immunoregulatory effects. TCM has demonstrated satisfactory therapeutic outcomes in uveitis treatment through multiple mechanisms. This article provides a comprehensive review of recent animal studies and clinical research concerning the application of Traditional Chinese Medicine in uveitis treatment, offering valuable insights for its clinical implementation.

KEYWORDS

Traditional Chinese Medicine, Uveitis, Treatment

CITE THIS PAPER

Qing Gao, Houpan Song, Advances in the Treatment of Uveitis with Traditional Chinese Medicine. MEDS Chinese Medicine (2025) Vol. 7: 131-137. DOI: http://dx.doi.org/10.23977/medcm.2025.070317.

REFERENCES

[1] Yin L, Ma C, Hou S, et al. Methyltransferase-like (METTL)14-mediated N6-methyladenosine modification modulates retinal pigment epithelial (RPE) activity by regulating the methylation of microtubule-associated protein (MAP)2[J]. Bioengineered, 2022, 13(3): 4773-4785.
[2] Pepple K L, Wilson L, Van Gelder R N, et al. Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand[J]. Translational Vision Science & Technology, 2019, 8(5): 11. 
[3] Zhang T, Liu Z, Li N. The application of dexamethasone implants in uveitis treatment[J]. Frontiers in Medicine, 2024, 11: 1402396.
[4] Lorenzo-Veiga B, Diaz-Rodriguez P, Alvarez-Lorenzo C, et al. In Vitro and Ex Vivo Evaluation of Nepafenac-Based Cyclodextrin Microparticles for Treatment of Eye Inflammation[J]. Nanomaterials, 2020, 10(4): 709.
[5] FALLON J, NARAYAN S, LIN J, et al. The impact of polymerase chain reaction (PCR) on diagnosis and management of infectious uveitis at a tertiary care facility[J]. Journal of Ophthalmic Inflammation and Infection, 2022, 12: 1.
[6] CHEN Y, LI Z, LI H, et al. Apremilast Regulates the Teff/Treg Balance to Ameliorate Uveitis via PI3K/AKT/FoxO1 Signaling Pathway[J]. Frontiers in Immunology, 2020, 11: 581673.
[7] NAMBA K, KABURAKI T, TSURUGA H, et al. Long-Term Safety and Effectiveness of Adalimumab in Japanese Patients with Noninfectious Intermediate, Posterior, or Panuveitis: Post-Marketing Surveillance of 251 Patients[J]. Ophthalmology and Therapy, 2022, 11(3): 1147-1161.
[8] SONG J, BI H, XIE X, et al. Preparation and evaluation of sinomenine hydrochloride in situ gel for uveitis treatment[J]. International Immunopharmacology, 2013, 17(1): 99-107.
[9] LI S, LIU F, ZHANG K, et al. Research Progress on the Mechanism of Natural Product Ingredients in the Treatment of Uveitis[J]. Journal of Immunology Research, 2021, 2021: 6683411.
[10] Li Jiangwei, Zhang Yanxue, Peng Jingxian, et al. Experience of Peng Qinghua in treating autoimmune uveitis by staging syndrome differentiation[J]. Chinese journal of traditional Chinese medicine, 2023, 64(23): 2393-2396+2406.
[11] Yin Xuewei, Guo Lijie, Zhou Mengxian, et al. Regulatory effect of Longdan Xiegan Decoction on M1/M2 macrophage polarization balance in rats with experimental autoimmune uveitis[J]. Recent advances in ophthalmology, 2021, 41(5): 408-412.
[12] Wang Huibo, Wei Qiping. Professor Wei Qiping's experience in treating iridocyclitis[J]. Chinese journal of traditional Chinese medical ophthalmology, 2015, 25(3): 204-206.
[13] Bi Xuqi, Li Lihong, Zhu Xiaoying, et al. Brief analysis on treating uveitis from "heat, toxin, dampness, stasis and deficiency"[J]. Chinese journal of traditional Chinese medical ophthalmology, 2022, 32(11): 879-882.
[14] Ma Liang. Efficacy of Qinggan Mingmu Decoction in treating 30 cases of acute anterior uveitis[J]. World latest medical information abstracts, 2019, 19(50): 232.
[15] Zhang Dandan, Yao Jing, Sun He, et al. Clinical observation of Shuanglian Mingmu Decoction in treating acute anterior uveitis of liver-gallbladder fire blazing type[J]. Chinese journal of traditional Chinese medical ophthalmology, 2023, 33(7): 627-631.
[16] Li Hong. Yiyang Jiulian Powder combined with western medicine in treating 30 cases of acute anterior uveitis of wind-dampness complicated with heat type[J]. Research of traditional Chinese medicine, 2019, 32(6): 15-18.
[17] Yang Fang, Qi Yingqiang, Dang Xiuhong, et al. Efficacy analysis of Yangyin Liangxue Decoction combined with glucocorticoid in treating 78 elderly patients with chronic uveitis[J]. China foreign medical treatment, 2017, 36(4): 135-136+139. 
[18] Li Y Z, Peng X, Ma Y H, et al. Matrine suppresses lipopolysaccharide-induced fibrosis in human peritoneal mesothelial cells by inhibiting the epithelial-mesenchymal transition[J]. Chinese medical journal, 2019, 132(6): 664-670.
[19] Deng Zhen, Wu Yifeng, Jiang Lei, et al. Kushenjian Eye Drops regulate TLR4/NF-κB pathway to affect the expression of related cytokines in rabbits with experimental uveitis[J]. Chinese journal of general practice, 2020, 18(4): 568-572+669.
[20] Yang Y, Wang Q, Xie M, et al. Berberine exerts an anti-inflammatory role in ocular Behcet’s disease[J]. Molecular medicine reports, 2017, 15(1): 97-102.
[21] Burkholder B M, Jabs D A. Uveitis for the non-ophthalmologist[J]. BMJ (Clinical research ed.), 2021, 372: m4979.
[22] Bai L L, Chen H, Zhou P, et al. Identification of tumor necrosis factor-alpha (TNF-α) inhibitor in rheumatoid arthritis using network pharmacology and molecular docking[J]. Frontiers in pharmacology, 2021, 12: 690118.
[23] Geng Q, Liu B, Ma Y, et al. Effects and safety of the tripterygium glycoside adjuvant methotrexate therapy in rheumatoid arthritis: a systematic review and meta-analysis[J]. Evidence-based complementary and alternative medicine: eCAM, 2022, 2022: 1251478.
[24] Pang Binbin, Xia Qinyun, Chen Zhen, et al. Anti-inflammatory effect of celastrol in ocular tissues of mice with experimental autoimmune uveitis (EAU) and its influence on microglial polarization[J]. Recent advances in ophthalmology, 2024, 44(1): 30-34+38.
[25] Zhao L, Zhu Y, Jia H, et al. From plant to yeast—advances in biosynthesis of artemisinin[J]. Molecules, 2022, 27(20): 6888.
[26] YIN X, QIU Y, LI Z, et al. Longdan Xiegan Decoction alleviates experimental autoimmune uveitis in rats by inhibiting Notch signaling pathway activation and Th17 cell differentiation[J]. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2021, 136: 111291.
[27] Zhu Dingyao. Effects of Qufeng Huoxue Pills on serum IL-2 and Foxp3 in rats with experimental autoimmune uveitis[D]. Hunan University of Chinese Medicine, 2021.
[28] Gao Jian. Effects of Qufeng Huoxue Pills on the expression of Bcl-2, Bax and Caspase-3 in retina of rats with experimental autoimmune uveitis[D]. Hunan University of Chinese Medicine, 2020.
[29] Yuan Lifei, Liu Jingna, Zhang Yue, et al. Therapeutic effect and anti-inflammatory mechanism of Qingre Mingmu Granules on rats with experimental autoimmune uveitis[J]. Chinese journal of traditional Chinese medical ophthalmology, 2021, 31(11): 770-775+782. 
[30] Jin Tingheng. Clinical efficacy of modified Danzhi Xiaoyao Powder on acute uveitis of liver-gallbladder fire blazing type and its influence on cytokines[J]. Journal of Chinese medicinal materials, 2018, 41(1): 225-227.
[31] Wei Dong, Zhang Weidao, Zhou Wanyu. Clinical study of modified Simiao Yong'an Decoction in the treatment of uveitis[J]. Chinese journal of traditional Chinese medical ophthalmology, 2020, 30(10): 741-744. 
[32] Lin Zhihui. Clinical observation of traditional Chinese medicine eye fumigation in the intervention treatment of uveitis[J]. China practical medicine, 2014, 9(29): 145.
[33] Zou Pingping, Jiang Tingting, Qin Mingming. Clinical study of Juhuang Xunyan Formula in adjuvant treatment of uveitis with liver-gallbladder fire blazing syndrome[J]. New Chinese medicine, 2021, 53(2): 135-138.
[34] Liu Jingjing, Cui Hao, Fu Shaoying, et al. Clinical observation of traditional Chinese medicine eye fumigation in the treatment of anterior uveitis[J]. Journal of traumatic medicine, 2004(4): 22-23.
[35] Zhao Jianying, Li Haiping, Hao Xiaobo, et al. Study on the changes of IFN-γmRNA/IL-4 mRNA expression in peripheral blood of rats with experimental autoimmune uveitis treated by acupoint catgut embedding[J]. Journal of Chinese ophthalmology and otorhinolaryngology, 2019, 9(2): 66-70.
[36] Zheng Fengming, Hao Xiaobo, Zhao Jianying, et al. Therapeutic effect of acupoint catgut embedding on experimental autoimmune uveitis in rats[J]. Chinese journal of traditional Chinese medical ophthalmology, 2015, 25(5): 309-313.
[37] Jiang Hongfen, Jiang Qiu'er. Clinical observation of acupoint catgut embedding in the treatment of refractory uveitis[J]. New Chinese medicine, 2017, 49(2): 141-143.
[38] Zhang Dan. Efficacy analysis of syndrome differentiation of traditional Chinese medicine combined with iontophoresis in the treatment of uveitis[J]. China medicine and pharmacy, 2012, 2(9): 100+102.
[39] Shang Yunbo. Clinical observation of direct current iontophoresis of traditional Chinese medicine in the treatment of uveitis[J]. Electronic journal of clinical medical literature, 2015, 2(36): 7425+7428.
[40] Han Guanyu, Bi Hongsheng, Xie Xiaofeng. Clinical study of traditional Chinese medicine iontophoresis in the treatment of anterior uveitis of wind-heat in liver meridian type[J]. Shandong journal of traditional Chinese medicine, 2013, 32(1): 9-10.

Downloads: 8982
Visits: 573103

Sponsors, Associates, and Links


All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.