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  4. Vol 7, Issue 3, 2025

Exploration on the Active Ingredients and Mechanisms of Ganjiang Lingzhu Decoction in the Treatment of Lumbar Disc Herniation: A Network Pharmacology Approach

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DOI: 10.23977/medcm.2025.070318 | Downloads: 11 | Views: 147

Author(s)

Wan Mengnan 1, Hu Jiang 2

Affiliation(s)

1 Chengdu Sport University, Chengdu, Sichuan, 610041, China
2 Sichuan Provincial People’s Hospital, Chengdu, Sichuan, 610072, China

Corresponding Author

Hu Jiang

ABSTRACT

This study aims to systematically explore the active ingredients, key targets, and potential molecular mechanisms of Ganjiang Lingzhu Decoction (GJLZD) in the treatment of Lumbar Disc Herniation (LDH) using a network pharmacology approach. Active ingredients and potential targets of GJLZD were retrieved from the TCMSP database, while LDH-related targets were collected from the GeneCards database. A protein-protein interaction (PPI) network was constructed using the STRING database to identify core targets, and KEGG pathway enrichment analysis was performed via the DAVID platform. Resultly, the findings suggest that GJLZD exerts its therapeutic effects primarily through core active components such as quercetin, kaempferol, 7-Methoxy-2-methyl isoflavone, vestitol, and beta-sitosterol. These components act on key targets including AKT1, TNF, IL1B, IL6, and TP53. Significant enrichment was observed in pathways such as Lipid and Atherosclerosis, IL-17 signaling pathway, and Fluid Shear Stress and Atherosclerosis. These pathways collectively regulate biological processes including inflammatory response, apoptosis, and extracellular matrix metabolism. In conclusion, this study preliminarily reveals that GJLZD treats LDH through a synergistic mechanism involving "multi-component, multi-target, and multi-pathway" interactions, providing a theoretical foundation for further experimental validation and clinical application. 

KEYWORDS

Lumbar Disc Herniation, Ganjiang Lingzhu Decoction, Network Pharmacology, Mechanism of Action

CITE THIS PAPER

Wan Mengnan, Hu Jiang, Exploration on the Active Ingredients and Mechanisms of Ganjiang Lingzhu Decoction in the Treatment of Lumbar Disc Herniation: A Network Pharmacology Approach. MEDS Chinese Medicine (2025) Vol. 7: 138-147. DOI: http://dx.doi.org/10.23977/medcm.2025.070318.

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