Author(s)

Wanying Zhai ¹, Jiabin Tian ²

Affiliation(s)

¹ The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China
² Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, 518020, China

Corresponding Author

Jiabin Tian

ABSTRACT

This study aimed to explore the effects of comprehensive interventions on inflammation, negative emotions, and skin lesions in patients with atopic dermatitis (AD) and type 2 inflammation. A total of 120 patients with mild to moderate atopic dermatitis were selected and randomly divided into the observation group and the control group, with 60 cases in each group. The observation group received psychological intervention, emotional regulation training, dietary control, and exercise intervention in addition to conventional treatment. The control group received only conventional treatment. Before and after the treatment, inflammation markers (IL-4, IL-5, IL-13), negative emotions (HAM-D, SAS), and skin lesions (SCORAD) were assessed. In the observation group, after treatment, IL-4 decreased from 350.2 pg/mL to 210.5 pg/mL (P < 0.05), IL-5 decreased from 45.1 pg/mL to 30.2 pg/mL (P < 0.05), and IL-13 decreased from 75.3 pg/mL to 55.0 pg/mL (P < 0.05). Negative emotions improved, with HAM-D scores decreasing from 18.6 to 12.3 and SAS scores decreasing from 61.3 to 51.4 (P < 0.05). Skin lesions improved, with SCORAD scores decreasing from 26.4 to 18.2 (P < 0.05). No significant changes were observed in the control group. Comprehensive interventions effectively improve inflammation, negative emotions, and skin lesions in patients with atopic dermatitis, showing promising clinical application prospects.

KEYWORDS

Atopic Dermatitis; Type 2 Inflammation; Negative Emotions; Psychological Intervention; Skin Lesions

CITE THIS PAPER

Wanying Zhai, Jiabin Tian, Atopic Dermatitis with Type 2 Inflammation Comorbidity, Negative Emotional Issues and Solutions. MEDS Clinical Medicine (2025) Vol. 6: 110-114. DOI: http://dx.doi.org/10.23977/medsc.2025.060516.

REFERENCES

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[3] Liu Peizheng, Wang Qun, Zhao Jianshuai, et al. The Circuits and Molecular Mechanisms of Chronic Pain-Induced Anxiety and Depression. Journal of Neuroanatomy, 2025, 41(02): 231-235. (in Chinese)
[4] Wang Xiaoke, Shu Qing. Research Progress on the Neural Interaction Mechanisms of Chronic Pain and Negative Emotions and Comprehensive Intervention Strategies. Journal of Sun Yat-sen University (Medical Sciences Edition), 2025, 46(02): 197-209. (in Chinese)
[5] Wang Zhiming, Qin Cheng, Wang Fang, et al. Research Progress on Single-Cell Sequencing in the Classification of Atopic Dermatitis Cell Subsets. Chinese Journal of Dermatology and Venereology, 2024, 38(10): 1174-1180. (in Chinese)
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