Author(s)

Ximin Peng ¹

Affiliation(s)

¹ Shenshan Medical Center, Memorial Hospital of Sun Yat-Sen University, Shanwei, China

Corresponding Author

Ximin Peng

ABSTRACT

Lower extremity deep vein thrombosis (LEDVT) represents a significant perioperative complication in patients undergoing surgical management of gynecological malignancies. Despite advances in surgical techniques, anesthesia, and perioperative care, the incidence of LEDVT remains substantial, ranging from 5% to 25% depending on patient characteristics, tumor type, and procedural factors. The present study aimed to systematically analyze the risk factors associated with LEDVT following gynecologic oncologic surgery by reviewing current literature and cohort studies. Key predictors identified include advanced age, obesity, high-stage ovarian cancer, prolonged operative time, significant intraoperative blood loss, extensive lymphadenectomy, perioperative transfusion, and insufficient prophylactic anticoagulation. This analysis underscores the necessity of individualized risk assessment, evidence-based thromboprophylaxis, and early postoperative mobilization to mitigate LEDVT incidence and improve patient outcomes.

KEYWORDS

Deep Vein Thrombosis, Gynecological Malignancies, Surgery, Risk Factors, Thromboprophylaxis, Venous Thromboembolism

CITE THIS PAPER

Ximin Peng, Analysis of Risk Factors for Lower Extremity Deep Vein Thrombosis Following Surgery for Gynecological Malignancies. MEDS Clinical Medicine (2025) Vol. 6: 1-5. DOI: http://dx.doi.org/10.23977/medsc.2025.060601.

REFERENCES

[1] Zhang T, Chen Z, Fu H. Risk Factors for Postoperative Venous Thromboembolism in Patients With Gynecologic Malignancies: A Meta-analysis[J]. American Journal of Clinical Oncology, 2025: 10.1097.
[2] Cheng S, Gao H, Li Y, et al. Analysis of risk factors of postoperative lower extremity deep venous thrombosis in patients with cervical cancer[J]. Clinical and Applied Thrombosis/Hemostasis, 2024, 30: 10760296241240747.
[3] Pan J, Zhao G. Meta-analysis of Risk Factors for Venous Thromboembolism in Patients with Gynecologic Malignant Tumors[J]. Alternative Therapies in Health and Medicine, 2024, 30(12): 416-423.
[4] Chen X, Hou M, Wang D. Machine learning-based model for prediction of deep vein thrombosis after gynecological laparoscopy: A retrospective cohort study[J]. Medicine, 2024, 103(1): e36717.
[5] Utsugi K, Ishizuka N, Nomura H, et al. A 5-year prospective assessment of risk factors for lower limb lymphedema after gynecologic cancer surgery[J]. Scientific Reports, 2025, 15(1): 26371.
[6] Meng Z, Liu L, Yang X, et al. High preoperative D-dimer levels increase the risk of venous thromboembolism after gynecological tumor surgeries: a meta-analysis of cohort studies[J]. Research and Practice in Thrombosis and Haemostasis, 2025: 102690.
[7] Jin Z Y, Li C M, Zheng K, et al. Nomogram for predicting pulmonary embolism in gynecologic inpatients with isolated distal deep venous thrombosis[J]. International Journal of Gynecology & Obstetrics, 2024, 164(1): 324-333.

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