Author(s)

Guangzhi Zeng ¹, Zhihong Liu ², Caiyong Lu ¹

Affiliation(s)

¹ Liu Tie Central Hospital, Liuzhou, Guangxi, 541001, China
² The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China

Corresponding Author

Zhihong Liu

ABSTRACT

To investigate the clinical efficacy of a dual plasma molecular adsorption system combined with plasma exchange in the treatment of acute and chronic liver failure. Clinical data of 60 patients with acute and chronic liver failure were collected from January 2024 to July 2025 for study. The patients were divided into a control group (n=30) and an observation group (randomized using a random number table). The control group received plasma exchange alone, while the observation group received dual plasma adsorption plus plasma exchange. The clinical treatment outcomes, liver function, coagulation function, and inflammatory factor levels were compared between the two groups. The study data showed that after corresponding treatments, the clinical total effective rate in the observation group was significantly superior to that in the control group. In terms of liver function indicators, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, and direct bilirubin in the observation group were significantly lower than those in the control group. Coagulation function tests revealed that the prothrombin time and activated partial thromboplastin time in the observation group were significantly prolonged compared to the control group. Additionally, in terms of inflammatory markers, the levels of C-reactive protein (CRP) and procalcitonin in the observation group were also lower than those in the control group, with statistically significant differences between the groups (P <0.05). The combined treatment approach can effectively improve liver function and coagulation function, reduce inflammatory factors in the body, and enhance treatment efficacy.

KEYWORDS

Acute and Chronic Liver Failure; Dual Plasma Adsorption; Plasma Exchange; Liver Function

CITE THIS PAPER

Guangzhi Zeng, Zhihong Liu, Caiyong Lu. Application of Double Plasma Adsorption Combined with Plasma Exchange in Patients with Acute and Chronic Liver Failure. MEDS Clinical Medicine (2026). Vol. 7, No.1, 124-130. DOI: http://dx.doi.org/10.23977/medsc.2026.070112.

REFERENCES

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