Research Advances in the Molecular Biological Mechanisms of Depleted Uranium–Induced Renal Injury

Shen Jiang; Teng Zhang; Xiaona Gu

doi:10.23977/phpm.2026.060106

Research Advances in the Molecular Biological Mechanisms of Depleted Uranium–Induced Renal Injury

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DOI: 10.23977/phpm.2026.060106 | Downloads: 0 | Views: 63

Author(s)

Shen Jiang ¹, Teng Zhang ¹, Xiaona Gu ¹

Affiliation(s)

¹ China Institute for Radiation Protection, Taiyuan, Shanxi Province, China

Corresponding Author

Xiaona Gu

ABSTRACT

Against the backdrop of the development of nuclear energy technologies and the application of uranium-containing weapons, the health effects induced by depleted uranium (DU) have attracted increasing attention. As the primary organ for DU accumulation in the human body, the kidney is highly susceptible to DU-induced toxicity. The mechanisms underlying DU-induced renal injury mainly involve oxidative stress, mitochondrial structural and functional dysfunction, and cell death. However, detailed elucidation of these pathogenic mechanisms remains insufficient. Therefore, this review systematically summarizes the molecular biological mechanisms of DU-induced renal injury, with the aim of providing a theoretical basis for subsequent animal experiments and population-based epidemiological studies.

KEYWORDS

depleted uranium, renal injury, molecular mechanisms, kidney

CITE THIS PAPER

Shen Jiang, Teng Zhang, Xiaona Gu. Research Advances in the Molecular Biological Mechanisms of Depleted Uranium–Induced Renal Injury. MEDS Public Health and Preventive Medicine (2026). Vol. 6, No.1, 43-53. DOI: http://dx.doi.org/10.23977/phpm.2026.060106.

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Research Advances in the Molecular Biological Mechanisms of Depleted Uranium–Induced Renal Injury

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