Intelligent structure prediction and visualization analysis Aof macrophage-mediated immunomodulation in spinal cord injury repair research

Chenyu Zhu; Longhao Chen; Lijiang Lv; Zhizhen Lv

doi:10.23977/medsc.2026.070120

Intelligent structure prediction and visualization analysis Aof macrophage-mediated immunomodulation in spinal cord injury repair research

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DOI: 10.23977/medsc.2026.070120 | Downloads: 102 | Views: 140

Author(s)

Chenyu Zhu ^1,2, Longhao Chen ^1,3, Lijiang Lv ^1,3, Zhizhen Lv ^1,3

Affiliation(s)

¹ The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
² The Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
³ The Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China; Research Institute of Tuina (Spinal disease), Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

Corresponding Author

Lijiang Lv

ABSTRACT

Spinal cord injury (SCI) is a devastating global neurological disorder, and immunomodulation is critical to SCI repair. This study aimed to explore the roles of macrophages and immunomodulation in SCI repair, establish a relevant knowledge base, and identify research trends and hotspots. Articles on SCI and related immunomodulation up to November 2024 were retrieved from the Web of Science Core Collection, and bibliometric analyses were performed using bibliometrix, Citespace, VOSviewer and other tools to visualize cooperation networks and quantify authors, countries, institutions, journals and keywords.A total of 894 papers from 49 countries were included, with China being the most productive (315 papers). Ohio State University, Phillip G. Popovich, and Journal of Neuroinflammation were the most influential institution, author and journal respectively. Key hotspots included axonal regeneration and related neuroimmune models. In conclusion, macrophages—particularly the balance between M1 and M2 phenotypes—play a critical role in neural recovery following SCI. While the body of research in this area is growing, enhanced international and inter-institutional collaboration remains essential to advance this field and benefit patients with spinal cord injuries.

KEYWORDS

Spinal cord injury, macrophages, immunomodulation, bibliometrics, regulatory mechanisms, global trends

CITE THIS PAPER

Chenyu Zhu, Longhao Chen, Lijiang Lv, Zhizhen Lv. Intelligent structure prediction and visualization analysis Aof macrophage-mediated immunomodulation in spinal cord injury repair research. MEDS Clinical Medicine (2026). Vol. 7, No.1, 201-219. DOI: http://dx.doi.org/10.23977/medsc.2026.070120.

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Intelligent structure prediction and visualization analysis Aof macrophage-mediated immunomodulation in spinal cord injury repair research

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ABSTRACT

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