Author(s)

Gloria Kuai ¹, Lily Zheng ¹, Doris Dai ¹, Naizhuang Jake Wang ¹, Amelia Wang ¹, Mok Wai Fun ¹

Affiliation(s)

¹ ABINOSA LIMITED, 1500 N GRANT ST, STE C, Denver, Co 80203, US

Corresponding Author

Gloria Kuai

ABSTRACT

This study aimed to evaluate a novel lipid-encapsulated magnesium bisglycinate delivery system, CalmGly^TM, to overcome the challenges of low bioavailability and poor gastrointestinal tolerability associated with conventional magnesium salts (such as magnesium oxide). The formulation was prepared using high-pressure homogenization combined with spray drying. The system was characterized for encapsulation efficiency, particle size distribution, reconstitution behavior, Caco-2 transepithelial transport capacity, and accelerated stability. Results showed that CalmGly^TM exhibited a high encapsulation efficiency of 88.5%, with an average particle size of 168.5 nm and a PDI of 0.18. In the Caco-2 monolayer model, the apparent permeability coefficient (P_app) of CalmGly^TM reached 1.88×10⁻⁵ cm/s, which was approximately 10.4 times that of the magnesium oxide control (0.18×10⁻⁵ cm/s). Furthermore, CalmGly^TM maintained a magnesium retention rate of 98.4% after 6 months of accelerated aging. In conclusion, CalmGly^TM exhibits high encapsulation efficiency and robust digestion stability, significantly enhancing the absorption rate of magnesium bisglycinate. This delivery system offers a promising new strategy for improving the efficacy of magnesium supplementation and reducing associated side effects.

KEYWORDS

Magnesium bisglycinate, Lipid encapsulation, CalmGlyTM, Bioavailability, Stability

CITE THIS PAPER

Gloria Kuai, Lily Zheng, Doris Dai, Naizhuang Jake Wang, Amelia Wang, Mok Wai Fun. Preparation, Physicochemical Characterization and Intestinal Transport Evaluation of CalmGly^TM, a Lipid-Encapsulated Magnesium Bisglycinate Delivery System. Social Medicine and Health Management (2026). Vol. 7, No. 2, 13-22. DOI: http://dx.doi.org/10.23977/socmhm.2026.070202.

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