Author(s)

Zhangying Meng ¹

Affiliation(s)

¹ North China University of Science and Technology, Tangshan, Hebei, 063210, China

Corresponding Author

Zhangying Meng

ABSTRACT

Objective: To explore the specific role of regulatory polypeptide Ac-SDKP in restraining silicosis fibrosis. Methods: The study starts from February 2020 to February 2021. 20 Wistar rats are selected as subjects of the study, and they are randomly divided into treatment group and model group. The treatment group is treated with anti-fibrosis of regulatory polypeptide Ac-SDKP, while the model group is not treated. And the expressions of p-CREB, PKA, and cAMP in the two groups of rats are observed. Results: The expressions of p-CREB, PKA and cAMP in the treatment group are higher than those in the model group (P < 0.05). Conclusion: Silicosis fibrosis can be inhibited by the regulatory polypeptide Ac-SDKP.

KEYWORDS

Silicosis fibrosis, Regulatory polypeptide ac-sdkp, P-creb, Pka, Camp

CITE THIS PAPER

Zhangying Meng. Research on Role of Regulatory Polypeptide Ac-Sdkp in Restraining Silicosis Fibrosis. MEDS Clinical Medicine (2021) 2: 6-9. DOI: http://dx.doi.org/10.23977/medsc.2021.020102.

REFERENCES

[1] Li Yaqian, Zhang Shihui, Zhang Yi, etc. The Regulatory Effect of Ac-SDKP on the Activation of Aging Signal of Alveolar Type II Epithelial Cells in Experimental Silicosis Fibrosis Model [J]. Chinese Journal of Comparative Medicine, 2021, 31(03):1 -7.
[2] Cai Wenchen, Zhang Shihui, Wei Zhongqiu, etc. The Mechanism of Ac-SDKP Inhibiting SPP1/TGF-β1 Signal and Antagonizing Experimental Silicosis [J]. Journal of Practical Medicine, 2021, 37(02): 159-163.
[3] Zhang Guizhen, Zhang Yi, Zhang Shihui, etc. The Effect and Mechanism of Ac-SDKP in Inhibiting SiO_2-Mediated Transformation of Alveolar Type II Epithelial MLE-12 Cells to Mesenchyme [J]. Journal of Kunming Medical University, 2020, 41(05) :41-45.
[4] Huang Fengzhang, Qin Yuhua, Liang Ming. Effect of Ac-SDKP on the Transdifferentiation of Renal Tubular Epithelial Cells of Rats Induced by TGF-β_1 [J]. Journal of Guangzhou Medical University, 2019, 47(03): 5-9+12 .
[5] Zhao Xing, Wang Min, Li Xingxin, etc. The Role of Regulatory Polypeptide Ac-SDKP in Anti-Silicosis Fibrosis and Its Research Progress [J]. China High-tech, 2017, 1(03): 40-42.

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