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  4. Vol 2, Issue 1, 2021

Hsa-Mir-29b-3p Inhibits Biological Development of Cancer by Targeting Inhibiting Expression of Cav2

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DOI: 10.23977/medsc.2021.020105 | Downloads: 6 | Views: 1080

Author(s)

BAI Wen-juan 1, LIU Yu 2

Affiliation(s)

1 Department of Biochemistry, College of Lab Medicine, Hebei North University, Zhangjiakou 075000, China
2 Laboratory Animal Center, Hebei North University, Zhangjiakou 075000, China

Corresponding Author

LIU Yu

ABSTRACT

Objective: To determine the role of hsa-miR-29b-3p in lung adenocarcinoma. Methods: Download miRNA mature for TCGA-LUAD, mRNA. from TCGA Database Differ differential analysis of miR-29b-3p based on the downloaded data obtained the differential gene expression matrix of miRNA and mRNA, and then intersects with the target genes predicted by multiple databases to obtain the target gene. Further KEGG enrichment analysis was performed on the target gene.Result:miR-29b-3p is significantly highly expressed in tumor tissue, its downstream regulated lower expression of the target gene CAV2 in cancer, and its lower expression indicates a better prognosis. KEGG enrichment results indicate significant enrichment of CAV2 in syndecan 2 pathway, Proteoglycans in cancer, ESR-mediated signaling, Signaling by Nuclear Receptors, Signal Transduction etc in Pathways associated with signal transduction and cell processes. Conclusion:hsa-miR-29b-3p suppresses cancer cell proliferation, adhesion, angiogenesis and metastasis, helping to inhibit the development of lung adenocarcinoma and can be used as a new therapeutic target.

KEYWORDS

Bioinformatics, Lung adenocarcinoma, Hyaluronic acid, Prognostic genes

CITE THIS PAPER

BAI Wen-juan, LIU Yu. Hsa-Mir-29b-3p Inhibits Biological Development of Cancer by Targeting Inhibiting Expression of Cav2. MEDS Clinical Medicine (2021) 2: 27-32. DOI: http://dx.doi.org/10.23977/medsc.2021.020105.

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