Education, Science, Technology, Innovation and Life
Open Access
Sign In

Explore the Future Direction of HIV-1 Latent Virus

Download as PDF

DOI: 10.23977/medsc.2021.020201 | Downloads: 5 | Views: 211

Author(s)

Jiaxin Liu 1

Affiliation(s)

1 Department of Biology, Baylor University, Waco, 76706, USA

Corresponding Author

Jiaxin Liu

ABSTRACT

Human immunodeficiency virus-1 (HIV-1) can be latent in quiescent CD4+ T cells, in which the viral DNA is silent in transcription and undetectable by the immune system. HIV-1 proviral DNA survives in the latent form primarily in quiescent CD4+ T cells. Although the current antiretroviral therapy (ART) can effectively inhibit the virus replication in HIV-1 infected people and suppress HIV to an undetectable level, ART does not work on latent HIV-1. Therefore, current ART cannot completely cure HIV-1 infected people, and HIV-1 infected people must use life-long ART to inhibit virus replication. Therefore, developing drugs that can act directly on latent HIV-1 is the biggest obstacle to the treatment of HIV-1 infection.

KEYWORDS

BRD4, HIV-1, Latency, Tat, Reactivation

CITE THIS PAPER

Jiaxin Liu. Explore the Future Direction of HIV-1 Latent Virus. MEDS Clinical Medicine (2021) 2: 1-3. DOI: http://dx.doi.org/10.23977/medsc.2021.020201.

REFERENCES

[1] Dahabieh, Matthew S et al. “Understanding HIV latency: the road to an HIV cure.” Annual review of medicine, vol.66, no.03, pp.407-421, 2015.

Downloads: 92
Visits: 4945

Sponsors, Associates, and Links


All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.