Author(s)

Qiong Wang ^1,2, Gesang Luobu ², Qijie Li ³, Hao Zhong ⁴, Kang Li ²

Affiliation(s)

¹ Medical College of Tibet University, Lhasa, Tibet 850000, China
² Institute of Plateau Medicine, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet 850000, China
³ West China Hospital of Sichuan University, Chengdu, Sichuan 610000, China
⁴ Chengdu Dashuo Experimental Animal Co., Ltd., Chengdu, Sichuan 610000, China

Corresponding Author

Kang Li

ABSTRACT

Background:Hypoxia is the most important characteristic at high altitude area, which can cause a series of changes in human physiological function.This study aims to observe the effect of high altitude polycythemia (HAPC) on the pathological characteristics of thymus in rats, and to provide histomorphological basis for the pathogenesis of HAPC. Methods: SD rats were randomly divided into two groups: normal control group and HAPC model group. The rats in the control group were fed with normal oxygen, and the rats in the model group were placed in a cabin simulating the altitude of 5000 m.The rats in the model group with 40 days of hypoxia, the HAPC model was successfully established. The RBC, HGB, HCT in the peripheral blood of all the rats were detected,the pathological morphology, ultrastructure and apoptosis were observed. Results: The levels of RBC, HGB and HCT in HAPC model group were significantly higher than those in control group (P < 0.01); the thymus in HAPC model group had obvious pathological damage, and the apoptosis rate was also significantly increased (P < 0.05). Conclusions: The thymus injury of rats with high altitude polycythemia mainly showed characteristic pathological changes such as lymphocyte atrophy,decreased number,cell necrosis and apoptosis.

KEYWORDS

Hapc, Thymus, Pathological characteristics, Apoptosis

CITE THIS PAPER

Qiong Wang, Gesang Luobu, Qijie Li, Hao Zhong, Yali Li, Kang Li, Analysis of Histopathology and Apoptosis Characteristics of Thymusb in Rats with High Altitude Polycythemia. MEDS Chinese Medicine (2021) 3: 123-128. DOI: http://dx.doi.org/10.23977/medcm.2021.030226

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