Author(s)

Zile Wang ¹, Hongsi Niu ², Yong Tang ³

Affiliation(s)

¹ Kunming Medical University, Kunming, China
² Yan’an Hospital Affiliated of Kunming Medical University, Kunming, China
³ First Affiliated Hospital of Kunming Medical University, Kunming, China

Corresponding Author

Yong Tang

ABSTRACT

Objective: To study the correlation between the serum expression levels of miR-143 and miR-145 and the incidence of SSNHL. Methods: 20 cases of SSNHL were collected as the experimental group, and 20 cases of normal hearing were collected as the control group. The expression levels of miR-143 and miR-145 in serum were detected by real-time fluorescence quantitative PCR method, and the t-test and Logistic regression analysis were used for statistical analysis. Results: The expression levels of serum miR-143 and miR-145 in SSNHL group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion: The expression levels of miR-143 and miR-145 in serum were highly correlated with the incidence of SSNHL.

KEYWORDS

SSNHL; miRNAs, Real-time fluorescence quantitative PCR

CITE THIS PAPER

Zile Wang, Hongsi Niu, Yong Tang. Correlation between Expression Level of Serum miRNAs and SSNHL. MEDS Clinical Medicine (2021) 2: 34-41. DOI: http://dx.doi.org/10.23977/medsc.2021.020208

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