Author(s)

Cunbo Wu ¹

Affiliation(s)

¹ Chongqing Mental Health Center, Gele Mmountain, Shapingba district, Chongqing, China

Corresponding Author

Cunbo Wu

ABSTRACT

Objective: To confirm whether levofloxacin is responsible for the seizure induced by cardiac arrest in elderly patients with schizophrenia. Methods: In the course of rescue, the blood cell analysis of emergency examination indicated infection, routine anti-infection treatment of levofloxacin injection after intravenous drip.  Results: The second day morning after successful rescue about cardiacarrest, this elderly schizophrenic patient developed a tonic-clonic seizure. The main manifestations are loss of consciousness, clenched teeth, muscle rigidity, foaming at the mouth, convulsions and so on. Conclusion: Levofloxacin intravenous infusion should be carefully used in elderly patients.  Levofloxacin intravenous infusion in elderly patients should be cautious, that it is very likely to induce seizures, or even life-threatening, resulting in unnecessary accidents.

KEYWORDS

Levofloxacin, epilepsy, cardiacarrest, schizophrenic patient

CITE THIS PAPER

Cunbo Wu, A Rare Case Report of Levofloxacin Intravenous Drip for Anti-Infection-Induced Epilepsy in Rescuing the Schizophrenic Patient after Cardiacarrest. MEDS Clinical Medicine (2022) Vol. 3: 36-39. DOI: http://dx.doi.org/10.23977/medsc.2022.030207.

REFERENCES

[1] Dai Z Y. (2004) Practical anti-infection therapeutics. People's Medical Publishing House, 81, 306. 
[2] Wang Z H, Zhang W W, and Feng Y F. (2011). Literature analysis of 296 cases of adverse reactions caused by levofloxacin. Journal of Pharmacoepidemiology, 20(8), 430-433. 
[3] Chen, Y. (2010). Analysis of neuropsychiatric symptoms caused by new-generation fluoroquinolones in the elderly. Chinese Community Physicians (11), 1. 
[4] Xu Z Q, He X M, Xiao W C. (2017). Clinical analysis of drug-induced encephalopathy in patients with maintenance hemodialysis. Chinese Journal of Integrated Traditional and Western Nephropathy, 18(11), 2. 
[5] Neame, M., King, C., Riordan, A., Iyer, A., Kneen, R., Sinha, I., & Hawcutt, D. B. (2020). Seizures and quinolone antibiotics in children: a systematic review of adverse events. European journal of hospital pharmacy: science and practice, 27(2), 60–64. https://doi.org/10.1136/ejhpharm-2018-001805.
[6] Scavone, C., Mascolo, A., Ruggiero, R., Sportiello, L., Rafaniello, C., Berrino, L., & Capuano, A. (2020). Quinolones-Induced Musculoskeletal, Neurological, and Psychiatric ADRs: A Pharmacovigilance Study Based on Data from the Italian Spontaneous Reporting System. Frontiers in pharmacology, 11, 428. https://doi.org/10.3389/fphar.2020.00428
[7] Xu J F. (2008). Population pharmacokinetics of levofloxacin: a pharmacodynamics study. (Dissertation, Fudan University), 5. 
[8] Shi L Y. (2011). Clinical analysis of 18 cases of chronic renal failure complicated with antibiotic encephalopathy.  Chinese Journal of Practical Medicine, 6(3), 183-184. 
[9] Kang, G., Min, S. H., Kim, J. K., & Kang, K. W. (2019). Association between the Levofloxacin Plasma Concentration and Neurological Adverse Events in an Elderly Patient. Journal of clinical neurology (Seoul, Korea), 15(4), 572–574. https://doi.org/10.3988/jcn.2019.15.4.572.
[10] Baik, S., Lau, J., Huser, V., & McDonald, C. J. (2020). Association between tendon ruptures and use of fluoroquinolone, and other oral antibiotics: a 10-year retrospective study of 1 million US senior Medicare beneficiaries. BMJ open, 10(12), e034844. https://doi.org/10.1136/bmjopen-2019-034844.

Sponsors, Associates, and Links

---

• Journal of Neurobiology and Genetics
  
  
• Medical Imaging and Nuclear Medicine
  
  
• Bacterial Genetics and Ecology
  
  
• Transactions on Cancer
  
  
• Journal of Biophysics and Ecology
  
  
• Journal of Animal Science and Veterinary
  
  
• Academic Journal of Biochemistry and Molecular Biology
  
  
• Transactions on Cell and Developmental Biology
  
  
• Rehabilitation Engineering & Assistive Technology
  
  
• Orthopaedics and Sports Medicine
  
  
• Hematology and Stem Cell
  
  
• Journal of Intelligent Informatics and Biomedical Engineering
  
  
• MEDS Basic Medicine
  
  
• MEDS Stomatology
  
  
• MEDS Public Health and Preventive Medicine
  
  
• MEDS Chinese Medicine
  
  
• Journal of Enzyme Engineering
  
  
• Advances in Industrial Pharmacy and Pharmaceutical Sciences
  
  
• Bacteriology and Microbiology
  
  
• Advances in Physiology and Pathophysiology
  
  
• Journal of Vision and Ophthalmology
  
  
• Frontiers of Obstetrics and Gynecology
  
  
• Digestive Disease and Diabetes
  
  
• Advances in Immunology and Vaccines
  
  
• Nanomedicine and Drug Delivery
  
  
• Cardiology and Vascular System
  
  
• Pediatrics and Child Health
  
  
• Journal of Reproductive Medicine and Contraception
  
  
• Journal of Respiratory and Lung Disease
  
  
• Journal of Bioinformatics and Biomedicine