Education, Science, Technology, Innovation and Life
Open Access
Sign In

Advances in the study of luteal support in assisted reproductive technology

Download as PDF

DOI: 10.23977/phpm.2022.020305 | Downloads: 12 | Views: 588

Author(s)

Rong Gao 1, Jianguo Liu 2, Xiaoguang Miao 1, Bin Guo 1

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, China
2 Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, China

Corresponding Author

Jianguo Liu

ABSTRACT

Assisted Reproductive Technology (ART) is a clinically effective method of assisting pregnancy. Luteal function can be affected by down regulation and ovulation promotion during ART, so routine luteal support is an essential part of the ART process, improving clinical pregnancy and live birth rates while achieving good and stable pregnancy outcomes. At present, there is still no consensus on luteal corpus luteum support scheme and medication selection. This paper therefore discusses the dosage, dose, route, safety and efficacy of luteal support drugs in recent years to clarify the clinical significance of luteal support in assisted reproduction and to provide a reference for the clinical selection of a reasonable luteal support regimen to improve the outcome of ART assisted pregnancy.

KEYWORDS

Luteal support, Luteal insufficiency, Assisted reproductive technology, Progesterone

CITE THIS PAPER

Rong Gao, Jianguo Liu, Xiaoguang Miao, Bin Guo, Advances in the study of luteal support in assisted reproductive technology. MEDS Public Health and Preventive Medicine (2022) Vol. 2: 25-32. DOI: http://dx.doi.org/10.23977/phpm.2022.020305.

REFERENCES

[1] CARSON SA, KALLEN A N. Diagnosis and treatment of infertility: a review [J]. Journal of the American Medical Association, 2021, 326(1): 65-76.
[2] Vander Borght M, Wyns C, Fertility and infertility: Definition and epidemiology [J]. Clinical Biochemistry, 2018, 62: 2-10.
[3] Xu H, Li YD, Fu J, et al. Etiological analysis of 23,317 infertile women in assisted reproduction clinics [J]. Chinese Journal of Reproduction and Contraception, 2019(09): 750-755.
[4] Liao Jia, Ma Qianhong, Xu Liangzhi. Etiology and management principles of decreased fertility due to non-ovarian factors [J]. Journal of Practical Obstetrics and Gynecology, 2021, 37(10): 731-734.
[5] Yin X. J, Li K. M, Duan T. Changes in luteinizing hormone secretion during pregnancy and its clinical significance [J]. Chinese Journal of Practical Gynecology and Obstetrics, 2021, 37(04): 414-417.
[6] Csapo AI, Pulkkinen MO, Wiest WG. Effects of lutectomy and progestreone replacement therapy in early pregnancy patients [J]. Am J Obstet  Gynecol, 1973, 115(6): 759-765. 
[7] Li XY, Zhou Xia, Cheng XQ, et al. Study on progesterone levels and its detection value during early pregnancy in natural pregnancy [J]. Journal of Reproductive Medicine, 2017, 26(02): 148-152.
[8] Marquardt RM, Kim TH, Shin JH, et al. Progesterone and estrogen signaling in the endometrium: what goes wrong in endometriosis? [J]. Int J Mol Sci, 2019, 20(15): 3822.
[9] Tian QJ. New advances in immune mechanisms of miscarriage and progestin preservation mechanisms [J]. Journal of Reproductive Medicine, 2020, 29(09): 1125-1131.
[10] Liu P. Luteal formation and the mechanism of luteal insufficiency [J]. Chinese Journal of Practical Gynecology and Obstetrics, 2021, 37(04): 412 - 414.
[11] Liu SJ. Clinical efficacy of tonifying the kidney and regulating the circumference method to improve endometrial tolerance in patients with luteal insufficiency infertility [D]. Tianjin University of Traditional Chinese Medicine, 2021.
[12] Clinical practice guidelines on progestogen maintenance of pregnancy and luteal support [J]. Chinese Journal of Reproduction and Contraception, 2021, 41(02): 95-105.
[13] Zhu D D, Zhang L X, Chen X P, et al. Analysis of clinical efficacy of two luteal support drugs on in vitro fertilization [J]. China Maternal and Child Health Research, 2020, 31(07): 975-978.
[14] Xu C X, Ying M H, Xu C, Zhou J, Yao J. Advances in the pharmacokinetics of progesterone and its derivatives [J]. Advances in Pharmacology, 2018, 42(05): 388-393.
[15] Liu SQ, Liu J, Long KX, et al. Adverse effects of progesterone preparations and rational clinical use [J]. Medical Theory and Practice, 2015, 28(20): 2836-2838.
[16] Li X.E, Zhang Shu, Min J. Research progress on new dosage forms of progesterone and their related applications [J]. Journal of Guangdong University of Pharmaceutical Sciences, 2019, 35(05): 697-701.
[17] Kaser DJ, Ginsburg ES, Missmer SA, et al. Intramuscular progesterone versus 8%Crinone vaginal gel for luteal phase support for day 3cryopreserved embryo transfer [J]. Fertil Steril, 2012, 98: 1464-1469. 
[18] Conforti A, Strina I, Mollo A, et al. The efficacy of modified luteal phase support with intramuscular progesterone in IVF/ICSI cycles: a retrospective observational study [J]. Eur Rev Med Pharmacol Sci, 2017, 21: 657-661.
[19] Chinese Medical Association, Reproductive Medicine Branch. Clinical Technical Practice Specification - Assisted Reproductive Technology and Sperm Banking Branch (2021 Revised Edition). Beijing: People's Health Publishing House, 2021: 41-42.
[20] Kahraman S, Karagozoglu SH, Karlikaya G. The efficiency of progesterone vaginal gel versus intramuscular progesterone for luteal phase supplementation in gonadotropin-releasing hormone antagonist cycles: aprospective clinical trial [J]. Fertil Steril., 2010, 94: 761-763. 
[21] Xue Yame, Tong Xiaomei, Zhang Songying. Meta-analysis of the effect of intramuscular progesterone injection versus vaginal extended-release gel on IVF-ET outcomes [J]. Chinese Journal of Reproduction and Contraception, 2015, 35: 252-258. 
[22] Wan Q, Lei ZW. Several issues of concern for progestogen to prevent miscarriage [J]. China Family Planning and Obstetrics and Gynecology, 2017, 9(11): 1-6+9.
[23] Rashidi BH, Ghazizadeh M, Nejad EST, et al. Oral dydrogesterone for luteal support in frozen-thawed embryo transfer artificial cycles: a pilot randomized controlled trial [J]. Asian Pacific J Reprod, 2016, 5(6): 490-494.
[24] Vander Linden MB, Farquhar C, Kremer JAM, et al. Luteal phase support for assisted reproduction cycles [CD]. Cochrane Data Syst Rev 2015(7): CD009154.
[25] Eddie Sun, Liu P, Ye H, et al. Consensus on luteal support and progesterone supplementation [J]. Reproduction and Contraception, 2015, 35(1): 1-8.
[26] Sun YQ, Zhang R, Gao L, et al. Changes in estrogen concentration after egg retrieval for predicting pregnancy outcome in fresh embryo transfer [J]. Journal of Reproductive Medicine, 2022, 31(03): 302-308.
[27] Pinheiro L, CndidoP, Moreto T C, et al. Estradiol use in the luteal phase and its effects on pregnancy rates in IVF cycles with GnRH antagonist: a systematic review [J]. JBRA Assist Reprod, 2017, 21: 247-250. 
[28] Pinheiro LMA, CndidoPDS, Moreto TC, et al. Estradiol use in the luteal phase and its effects on pregnancy ratesin IVF cycles with GnRH antagonist: a systematic review [J]. Jbra Assisted Reproduction, 2017, 21 (3): 247-250.
[29] Hu Y, Yao J, Li M. GnRH-a down-regulation in IVF or ICSI [J]. World abstract of the latest medical information, 2019, 19(08): 90-91+93.
[30] Tesarik J, Hazout A, Mendoza C. Enhancement of embryodevelopmental potential by a single administration of GnRH 2013(9): CD0000009278. 
[31] Zhou Huanyu, Wang Ying, Shi Yuhua. Advances in the clinical application of luteal phase ovulation promotion protocols [J]. Chinese Journal of Reproduction and Contraception, 2021, 41(12): 1134-1138.
[32] Zhu J R, Ou J P. Exploring the shortcomings and applicability of pituitary descending regimen [J]. Journal of Reproductive Medicine, 2016, 25(10): 893-896.
[33] ESHRE. ESHRE guideline: ovarian stimulation for IVF/ICSI [EB/OL]. [2019-12] (2020-01-11). http: //www.eshre.eu/guidelines.
[34] van der Linden M, Buckingham K, Farquhar C. Luteal phase support of assisted reproductive cycle [J]. Cochrane Database Syst Rev, 2015, 2015(7): CD009154.
[35] Xu XIA, Quan SONG. Exploration of luteal support in different ovulation promotion protocols [J]. Chinese Journal of Practical Gynecology and Obstetrics, 2021, 37(04): 417-422.
[36] Casper RF. Luteal phase support for frozen embryo transfer cycles: intramuscular or vaginal progesterone? [J]. Fertil Steril, 2014, 101(3): 627-628. 
[37] Orvieto R, Meltcer S, Volodarski M, et al. Luteal phase support for patients undergoing frozen-thawed embryo transfer cycles--the required progesterone dose[J]. Clin Exp Obstet Gynecol, 2007, 34(1): 25-26. 
[38] Alsbjerg B, Polyzos NP, Elbaek HO, et al. Increasing vaginal progesterone gel supplementation after frozen-thawed embryo transfer significantly increases the delivery rate [J]. Reprod Biomed Online, 2013, 26(2): 133-137.
[39] Chinese Medical Association, Reproductive Medicine Branch. Clinical guidelines on assisted reproductive technology and sperm banking (2021 revised edition). Beijing: People's Health Publishing House, 2021: 93-96.
[40] Chen ZJ, Lin QD, Wang XieTong, et al. Chinese expert consensus on progestogen maintenance of early pregnancy and prevention and control of miscarriage [J]. Chinese Journal of Obstetrics and Gynecology, 2016, 51(07): 481-483.
[41] Huang JY, Du BT. Prediction of early pregnancy outcome and treatment guidance by combined estrogen, progestin, and β-hCG levels [J]. Chinese Journal of Reproductive Health, 2018, 29(03): 274-276.
[42] Liu XR, Mu HQ, Shi Q, et al. The optimal duration of progesterone supplementation in pregnant women after IVF/ICSI: a meta-analysis [J]. Reprode Biol Endocrinol, 2012, 10: 107.

Downloads: 1960
Visits: 87952

Sponsors, Associates, and Links


All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.