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  4. Vol 3, Issue 4, 2022

Opioids Modulate the Mitochondrial Membrane Permeability Transition Pore to Improve Myocardial Ischemia-Reperfusion Injury Research Progress

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DOI: 10.23977/medsc.2022.030407 | Downloads: 15 | Views: 520

Author(s)

Jiashuo Li 1, Shu Song 1, Yibo Wang 1, Tianxiang Chen 1, Lili Gu 1, Mengyuan Tao 1, Shuhui Sun 1, Jinkun Xi 1, Wenji Liang 1, Xiaohan Yu 1, Zhumei Sun 1

Affiliation(s)

1 School of Clinical Medicine, North China University of Science and Technology, Tangshan, Hebei, 063000, China

Corresponding Author

Zhumei Sun

ABSTRACT

With the gradual improvement of cardiac surgery technology, the promotion and application of coronary artery thrombolysis, percutaneous coronary intraluminal plasty, cardiac surgery extracorporeal circulation and other technologies, myocardial ischemia and reperfusion injury, have attracted more and more attention from researchers. Myocardium ischemia-reperfusion injury (MIRI) is a more serious myocardial injury caused by reperfusion of ischemic myocardium, and there is often no effective treatment in the clinic, so how to avoid or alleviate MIRI has become a research hotspot. Studies have shown that mitochondria play a crucial role in myocardial protection, with mitochondrial permeability transition pores (mPTP) playing an essential role in MIRI. mPTP regulates mitochondrial membrane permeability to maintain mitochondrial stability, and opening mPTP will further worsen MIRI. Opioids such as Morphine, Fentanyl, Remifentanil, etc., are often used as analgesics in the clinic, but at present, they have been increasingly used in patients with MIRI injury. Opioids play a significant role in regulating mPTP opening, etc., and can regulate mPTP opening in various ways to inhibit MIRI effectively. This paper reviews the molecular mechanism and research progress of the occurrence and development of MIRI in recent years from many aspects further discusses the molecular mechanism and pathway of opioid regulation and intends to provide new ideas and theoretical basis for the prevention and treatment of MIRI.

KEYWORDS

Ischemia-reperfusion injury, mitochondrial membrane permeability transition pore, opioids, myocardium, Morphine, Fentanyl, Remifentanil

CITE THIS PAPER

Jiashuo Li, Shu Song, Yibo Wang, Tianxiang Chen, Lili Gu, Mengyuan Tao, Shuhui Sun, Jinkun Xi, Wenji Liang, Xiaohan Yu, Zhumei Sun, Opioids Modulate the Mitochondrial Membrane Permeability Transition Pore to Improve Myocardial Ischemia-Reperfusion Injury Research Progress. MEDS Clinical Medicine (2022) Vol. 3: 43-52. DOI: http://dx.doi.org/10.23977/medsc.2022.030407.

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