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Systematic Review and Meta-Analysis of Moluodan in Treatting Chronic Atrophic Gastritis

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DOI: 10.23977/medsc.2022.030504 | Downloads: 16 | Views: 608

Author(s)

Shangguan Xueli 1, Tang Liya 1

Affiliation(s)

1 Hunan University of Chinese Medicine, Changsha, 410208, China

Corresponding Author

Tang Liya

ABSTRACT

Objective: To evaluate the clinical efficacy of Moluodan in treating chronic atrophic gastritis by systematic review. Methods: Eight databases were retrieved, and the retrieval time is limited to August 2022. The published clinical trials of Moluodan in treating chronic atrophic gastritis were analyzed by Revman and TSA. Results: 2 studies and 592 cases were included. Compared with control group, Moluodan alone significantly improved the effective rate of disease detection [RR=1.73, 95% CI=(1.48,2.02), P<0.0001]. The trial sequential analysis showed that these results were conclusive. The funnel plot showed asymmetry of scattered points on both sides, suggesting that there may be publication bias. Conclusion: Moluodan can improve the efficiency of disease examination for patients with chronic atrophic gastritis, play a important role in slowing down the progress of chronic atrophic gastritis, and may have the value of further research.

KEYWORDS

Moluodan; chronic atrophic gastritis; meta analysis

CITE THIS PAPER

Shangguan Xueli, Tang Liya, Systematic Review and Meta-Analysis of Moluodan in Treatting Chronic Atrophic Gastritis. MEDS Clinical Medicine (2022) Vol. 3: 19-22. DOI: http://dx.doi.org/10.23977/medsc.2022.030504.

REFERENCES

[1] Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin. 2018, 68 (6):394-424.
[2] Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin. 2016, 66 (2):115-32.
[3] Zheng RT, Sun KX, Zhang SW, et al. [J]. Chinese Journal of Oncology, 2019(1):19-28.
[4] Correa P, Piazuelo MB. The gastric precancerous cascade [J]. J Dig Dis. 2012, 13 (1):2-9. 
[5] Fang YJ, Du YQ, Liu WZ, et al. Consensus on Chronic Gastritis in China (Shanghai, 2017) [J]. Chinese Journal of Gastroenterology, 2021, 22(11):670-687.
[6] Hao CJ, Li JY, Shen H, et al. Advance on Traditional Chinese Meidicine Clinical Researchof Precancerous Lesions of Gastric Cancer[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2021, 23(2):117-121.
[7] Peng WJ, Xiao GH, Chen SS. Reversal of Intestinal Metaplasia in Gastric Mucosa Treated with Traditional Chinese Medicine [J]. Asia-Pacific Traditional Medicine, 2017, 13(6):64-66.
[8] Liang JQ, Tan JY, Chen Q,et al. Clinical Observation of Chinese Medicine Syndrome Differentiation Individual Therapy on Precancerous Lesions of Gastric Cancer[J]. China Pharmacy, 2019, 30(24):3433-3436.
[9] He XD, Gong Y, Hu YQ, et al. Investigate of the clinical efficacy of Moluodan combined with vitamin E for the treatment of chronic atrophic gastritis with low-grade intraepithelial neoplasia [J]. Chinese Journal of Clinical Gastroenterology, 2017, 29 (5):294-296.
[10] Ding ZW. The safety analysis of Moluodan in the treatment of chronic gastritis [J]. China Journal of Pharmaceutical Economics, 2017, 12 (11):15-18+39.
[11] Tang XD, Fang YJ. Clinical Applicatian Guidelines on Chinese Patent Medicine in the Treatment for Chronic Gastritis (2020)[J]. Chinese Journal of Integrated Traditional and Western Medicine, 2021, 41 (2):157-163.
[12] Editorial Department of Chinese Community Doctors. Chinese medicine gastric precancerous lesions research draws European attention to new guidelines citing Chinese research results [J]. Chinese Community Doctors, 2020, 36 (15):144.
[13] Tang XD, Zhou LY, Zhang ST, et al. Randomized double-blind clinical trial of Moluodan for the treatment of chronic atrophic gastritis with dysplasia[J]. Chin J Integr Med, 2015, 22 (1), 9-18.
[14] Du AM, Yang X, Liu J, et al. A comparison of the treatment to the chronic atrophic gastritis by the folic acid combined with vitamin E and by Mo Luo Dan [J]. Clinical Journal of Traditional Chinese Medicine, 2015,27(12), 1717-1720.
[15] Kanai M, Togo R, Ogawa T, et al. Chronic atrophic gastritis detection with a convolutional neural network considering stomach regions [J]. World J Gastroenterol, 2020, 26 (25), 3650-3659. 
[16] Wei W, Yang Y. Current situation of diagnosis & treatment for chronic atrophic gastritis and treating advantages of chinese medicine [J]. Journal of Traditional Chinese Medicine, 2016, 57 (1), 36-40.
[17] Zhao Q, Chi T. Deep learning model can improve the diagnosis rate of endoscopic chronic atrophic gastritis: a prospective cohort study[J]. BMC Gastroenterol, 2022, 22(1), 133-133.
[18] He YQ. Clinical efficacy of folic acid combined with morodan in the treatment of chronic atrophic gastritis[J]. China & Foreign Medical Treatment, 2021,41(16), 88-91.

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