Education, Science, Technology, Innovation and Life
Open Access
Sign In
  1. Home
  2. Journals
  3. MEDS Chinese Medicine
  4. Vol 4, Issue 4, 2022

Research Progress on the Pharmacological Mechanism of Sour Date Palm in the Treatment of Insomnia with Anxiety and Depression

Download as PDF

DOI: 10.23977/medcm.2022.040407 | Downloads: 36 | Views: 989

Author(s)

Liduo Shen 1, Hui Zhang 2, Xiaoxiao Shao 1, Ruochen Jiang 1, Yuxin Jian 1

Affiliation(s)

1 Shaanxi University of Traditional Chinese Medicine, Xianyang, 712046, Shaanxi, China
2 Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, Shaanxi, China

Corresponding Author

Hui Zhang

ABSTRACT

Insomnia with anxiety and depression is one of the common psychological disorders, which are closely related and usually appear in the form of co-morbidity. The pathogenesis of this disease is still unclear, but it is mostly related to the function of the hypothalamic-pituitary-adrenal axis (HPA axis), neurotransmitter regulation, and inflammatory response. According to Chinese medicine, this disease belongs to the category of "sleeplessness", "depression" and "dirty restlessness", involving the five internal organs and six internal organs. Modern pharmacological studies have shown that sour date kernel contains flavonoids, saponins, triterpenoids, and phenolic acid compounds. It is also found to act simultaneously through sedative-hypnotic, anti-anxiety, anti-depressant, neurotransmitter regulation, inflammation inhibition, and brain nerve protection. In this paper, the pharmacological effects and mechanisms of the active ingredients of Ziziphus jujube were described by reviewing the pharmacological research literature related to Ziziphus jujube, to illustrate the positive efficacy and medicinal value of Ziziphus jujube in the treatment of insomnia with anxiety and depression.

KEYWORDS

Sour date palm, insomnia with anxiety and depression, saponins, pharmacological mechanism, flavonoids

CITE THIS PAPER

Liduo Shen, Hui Zhang, Xiaoxiao Shao, Ruochen Jiang, Yuxin Jian, Research Progress on the Pharmacological Mechanism of Sour Date Palm in the Treatment of Insomnia with Anxiety and Depression. MEDS Chinese Medicine (2022) Vol. 4: 44-49. DOI: http://dx.doi.org/10.23977/medcm.2022.040407.

REFERENCES

[1] Chiara Baglioni, Dieter Riemann. Is chronic insomnia a precursor to major depression? Epidemiological and biological findings [J]. Psychiatry Rep, 2012, 14(5): 511-5
[2] Hein M, Lanquart JP, Loas G, et al. Similar polysomnographic pattern in primary insomnia and major depression with objective insomnia: a sign of common pathophysiology? [J]. BMC Psychiatry, 2017, 17(1): 273. 
[3] Okajima I, Chen J. The effect of insomnia on changes in anxiety, depression, and social function after a transdiagnostic treatment targeting excessive worry [J]. Sleep Biol Rhythms, 2017, 15(3): 243-249.
[4] KRUEGE JM. The role of cytokines in sleep regulation [J]. Curr Pharm Des, 2008, 14 (32): 3408-3416. 
[5] INGIOSI AM, OPP MR, KRUEGER JM. Sleep and immune function: gial contributions and consequences of aging [J]. Curr Opin Neurobiol, 2013, 23 (5): 806-811.
[6] National Pharmacopoeia Committee. Pharmacopoeia of the People's Republic of China: a [M]. Beijing: China Medical Science and Technology Press, 2020: 382.
[7] Liu Y, Guan T, Liang Hodu, et al. Study on the pharmacological effects of sour date seeds to improve sleep and its mechanism [J]. Chinese Medicine Information, 2021, 38(3): 82-86.
[8] Ming-Li Shizhen. The compendium of materia medica. Taiyuan: Shanxi Science and Technology Press, 2014: 950, 1066
[9] Xia Juan, Zhao Zhiqiang. Analysis of the intra-set correlation of Jiaotai Pill based on the clinical cases of Zhou Zhongying, a national medical master [J]. Journal of Shandong University of Traditional Chinese Medicine, 2021, 45(05): 646-652. DOI: 10.16294/j.cnki.1007-659x.2021.05.016. 
[10] Yang Mengmeng, Li Dan, Zhang Huailiang. Professor Zhang Huai-Liang's experience in the treatment of depressive symptoms [J]. Asia-Pacific Traditional Medicine, 2021, 17(11): 120-122. 
[11] Sang Haiyan. The experience of Zhang Lei, a master of national medicine, in the treatment of neurological disorders by using Sleeping Peace Soup [J]. New Chinese Medicine, 2021, 53(04): 217-219. DOI: 10.13457/j.cnki.jncm.2021.04.055.
[12] Han P, Li J, Hu XY, Fu Q, Hu XX. Research progress on chemical composition, pharmacological effects, and clinical application of sour date kernel [J]. Journal of Traditional Chinese Medicine, 2021, 49(02): 110-114. DOI: 10.19664/j.cnki.1002-2392.210048. 
[13] FANG Shansheng, QU Xianhou, SU Xiaolan, YANG Yang, GUO Song, XU Chuchu, WEI Wei. Network pharmacology study on the action of sour date palm in neuropsychiatric diseases [J]. Liaoning Journal of Traditional Chinese Medicine, 2020, 47(07): 128-131+222. DOI: 10.13192/j.issn.1000-1719.2020.07.035.
[14] YUAN Y, WU W, CHEN M, et al. Reward Inhibits Paraventricular CRH Neurons to Relieve Stress [J]. Current Biology, 2019, 29(7): 1243-1256.
[15] RITTER P, BRANDT M, SCHREMPF W, et al. Role of the IL -6-Receptor expression in CD14 + monocytes in modulating sleep in patients with bipolar disorder [J]. Journal of Affective Disorders, 2018, 239: 152-160.
[16] KIM S, JO K, HONG KB, et al. GABA and l -theanine mixture decreases sleep latency and improves NREM sleep [J]. Pharmaceutical Biology, 2019, 57(1): 65-73.
[17] ELFIORE M, CARIATI I, MATTEUCCI A, et al. Calcitonin native prefibrillar oligomers but not monomers induce membrane damage that triggers NMDA -mediated Ca2 +- influx, LTP impairment, and neurotoxicity [J]. Scientific Reports, 2019, 9(1): 5144-5158.
[18] KUMAR A, DOGRA S, SONA C, et al. Chronic histamine 3 receptor antagonism alleviates depression-like conditions in mice via modulation of brain-derived neurotrophic factor and hypothalamus-pituitary-adrenal axis [J]. Psychoneuroendocrinology, 2018, 101: 128-137.
[19] IANG J G, HUANG X J, CHEN J, et al. Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen Ziziphus jujube [J]. Nat Prod Res, 2007, 21(4): 310 – 320.
[20] LI Y, ZHAO X, ZHANG Y, et al. Pharmacokinetic Study of Swertisin by HPLC - MS /MS After Intravenous Administration in Rats [J]. J Chromatogr Sci, 2017, 55(1): 40 – 46.
[21] Yan T X, Sun Y Y, Xiao F, et al. Schisandrae Chinensis Fructus inhibits behavioral deficits induced by sleep deprivation and chronic unpredictable mild stress via increased signaling of brain-derived neurotrophic factor [J]. Phytother Res, 2019, 33(12): 3177-3190.
[22] Zhao Qian, Li Jingcao, Wang Xiao, Zhang Youzhi. The role of experimental animals in the evaluation of Tianwang Tonic Heart Dan for the prevention and treatment of insomnia [J]. Chinese Journal of Comparative Medicine, 2022, 32(01): 120-126. 
[23] Okaty BW, Commons KG, Dymecki SM. Embracing diversity in the 5-HT neuronal system [J]. Nat Rev Neurosci, 2019, 20(7): 397-424.
[24] WANG L E, ZHANG X Q, YIN Y Q, et al. Augmentative effect of spinosin on pentobarbital - induced loss of righting reflex in mice associated with presynaptic 5 - HT1A receptor [J]. J Pharm Pharmacol, 2012, 64(2): 277-282.
[25] SUNG R, YOUNG J, JO S L, et al. Sanjoinine A isolated from Semen Zizyphi Spinosi protects against kainic acid-induced convulsions [J]. Archives of Pharmacal Research, 2009, 32(11): 1
[26] Sun Yan. Fingerprinting of alkaloids and saponins of Ziziphus jujube and the mechanism of antidepressant and tranquilizing effects [D]. Tianjin: Tianjin Medical University, 2014: 3 - 10. 
[27] Rwin MR, Opp MR. Sleep-health: reciprocal regulation of sleep and innate immunity [J]. Neuropsychopharmacology, 2016, 42(1): 129-155.
[28] Wichers MC, Maes M. The role of indoleamine 2,3-di⁃oxygenase (IDO) in the pathophysiology of interfer⁃ on-alpha-induced depression [J]. J Psychiatry Neurosci, 2004, 29(1): 11-17.
[29] BEUREL E, TOUPS M, NEMEROFF C B. The Bidirectional Relationship of Depression and Inflammation: Double Trouble [J]. Neuron, 2020, 107(2): 234-256.
[30] KöHLER-FORSBERG O, N LYDHOLM C, HJORTHøJ C, et al. Efficacy of anti-inflammatory treatment on a major depressive disorder or depressive symptoms: a meta-analysis of clinical trials [J]. Acta Psychiatr Scand, 2019, 139(5): 404-419.

Subscription
E-Mail Alert
Most popular papers
Call for Special Issue
Publication Ethics & OA Statement
Plagiarism Policy
Contact Us
Downloads: 4232
Visits: 167535

Sponsors, Associates, and Links

All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.