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The Primary Antitumor Activities Study of a Novel Peach Gum Oligosaccharide

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DOI: 10.23977/tranc.2020.020101 | Downloads: 14 | Views: 1145

Author(s)

Jinfeng Deng 1, Yanhong Ran 1

Affiliation(s)

1 Department of Bioengineering, College of Life Science, Jinan University, Guangdong, China

Corresponding Author

Yanhong Ran

ABSTRACT

The peach gum oligosaccharide (PGOP) we reported is a novel bio-degradation product of peach gum. Because of the bone structure is galactan, PGOP is expected has prebiotic and antitumor activity. This study investigates the activity of PGOP to inhibit the tumor cell proliferation and the tumor cell agglutination. The result showed that when the concentration of PGOP above 25 μg/ ml, the proliferation of Hela cell would be inhibited, and when above 50 μg/ ml, the viability of Hela cell would be inhibited either. PGOP can inhibit the cell agglutination mediated by galectin-3, and has a better inhibition than lactose. Finally, PGOP plays the role of prebiotic to promote the growth of probiotics, assists in anti-tumor.

KEYWORDS

peach gum oligosaccharide (PGOP), anti-tumor, galectin-3, probiotics

CITE THIS PAPER

Jinfeng Deng, Yanhong Ran. The Primary Antitumor Activities Study of a Novel Peach Gum Oligosaccharide. Transactions on Cancer (2020) 2: 1-6. DOI: http://dx.doi.org/10.23977/tranc.2020.020101.

REFERENCES

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