Author(s)

Panpan Bai ¹, Yongxue Zhou ¹, Xiaojuan Sun ¹

Affiliation(s)

¹ Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

Corresponding Author

Yongxue Zhou

ABSTRACT

To explore the mechanism of Angelica sinensis and Atractylodes macrocephala on the treatment of depression based on network pharmacology. the effective components of Angelica sinensis and Atractylodes macrocephala were obtained through TCMSP combined with literature retrieval; Predict drug component related targets in the database; Using online human Mendelian genetics (OMIM) database, Gene Cards, TTD, GRUGBANK database, and using "expression" as the keyword to obtain relevant disease targets; Draw Wayne diagram to get the potential target of Angelica Atractylodes macrocephala on the treatment of depression; Using String database and Cytoscape3 8.0 software to construct protein-protein interaction network and drug component disease target network of potential target; The biological process analysis and metabolic pathway analysis of Angelica Atractylodes macrocephala on the target of treating depression were carried out on metascape platform.

KEYWORDS

Angelica sinensis, Atractylodes macrocephala, Depression, Network pharmacology, Mechanism of action

CITE THIS PAPER

Panpan Bai, Yongxue Zhou, Xiaojuan Sun, Discussion on the Mechanism of Angelica Sinensis and Atractylodes Macrocephala on the Treatment of Depression Based on Network Pharmacology. MEDS Clinical Medicine (2022) Vol. 3: 22-29. DOI: http://dx.doi.org/10.23977/medsc.2022.030605.

REFERENCES

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