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  4. Vol 4, Issue 9, 2022

Research Progress of Traditional Chinese and Western Medicine in the Treatment of Lewy Body'S Dementia

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DOI: 10.23977/medcm.2022.040901 | Downloads: 10 | Views: 434

Author(s)

Shaocong Liu 1, Yali Wang 2, Yingmei Zhang 1, Renrui Chang 1, Renyan Zhu 1

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China

Corresponding Author

Yali Wang

ABSTRACT

Dementia with Lewy body (DLB) is a neurodegenerative disease characterized by fluctuating cognitive impairment, recurrent visual hallucinations and spontaneous Parkinson's syndrome. Although DLB has clear diagnostic criteria, its clinical manifestations are complex and difficult to diagnose. It can only be treated symptomatically and the prognosis is poor. By searching the relevant literature at home and abroad, the author summarizes and prospects the latest research progress in the pathogenesis, diagnosis, differentiation, and treatment of Lewy body dementia, hoping to provide reference for the clinical diagnosis and treatment of Lewy body dementia. 

KEYWORDS

Dementia with Lewy Body, Traditional Chinese and western medicine, Research progress, Review

CITE THIS PAPER

Shaocong Liu, Yali Wang, Yingmei Zhang, Renrui Chang, Renyan Zhu, Research Progress of Traditional Chinese and Western Medicine in the Treatment of Lewy Body'S Dementia . MEDS Chinese Medicine (2022) Vol. 4: 1-11. DOI: http://dx.doi.org/10.23977/medcm.2022.040901.

REFERENCES

[1] Stahnisch, F.W. and Koehler, P.J. (2012) Three 20th-century Multiauthored Handbooks Serving as Vital Catalyzers of an Emerging Specialization: A Case Study from the History of Neurology and Psychiatry. J Nerv Ment Dis, 200(12):1067—1075.
[2] Kane, J., Surendranathan, A., Bentley, A., et al. (2018) Clinical Prevalence of Lewy Body Dementia. Alzheimer's Research & Therapy, 10(1):19.
[3] Walker, Z., Possin, K.L., Boeve, B.F., et al. (2015) NonAlzheimer's Dementia 2: Lewy Body Dementias. Lancet, 386(10004):1683-1697.
[4] Liu, J. (2016) Progress in the Diagnosis and Treatment of Dementia with Lewy Bodies. Chinese Journal of Practical Internal Medicine, 36(11): 938-940+943.
[5] Mueller, C., Ballard, C., Corbett, A., et al. (2017) The Prognosis of Dementia with Lewy Bodies. Lancet Neurol, 16(5): 390-398.
[6] Hogan, D.B., Fiest, K.M., Roberts, J.I., et al. (2016) The Prevalence and Incidence of Dementia with Lewy Bodies: a Systematic Review. Can J Neurol Sci, 43(S1): S83-S95.
[7] Savica, R., Grossardt, B.R., Bower, J.H., et al. (2017) Survival and Causes of Death among People with Clinically Diagnosed Synucleinopathies with Parkinsonism: Apopulation-Based Study. JAMA Neurol, 74(7): 839-846.
[8] Zhu, F.L. and Jiao, F.Y. (2022) Etiology and Pathogenesis of Dementia. Journal of Practical Chinese Medicine Internal Medicine: 1-4. 
[9] Wang, F. and Wang, Z.L. (2019) A Preliminary Study on Traditional Chinese Medicine in the Treatment of Dementia with Lewy Bodies. Journal of Integrative Cardiovascular and Cerebrovascular Diseases, 17 (17): 2715-2716.
[10] Wang, J., Yu, Y.Y., Fu, D.T., et al. (2021) Etiology and Pathogenesis of Dementia with Lewy Body in Traditional Chinese Medicine, and Its Dialectical Treatment. Jilin Journal of Traditional Chinese Medicine, 41(05): 561-564.
[11] Nervi, A., Reitz, C., Tang, M.X., et al. (2011) Familial Aggregation of Dementia with Lewy Bodies. Arch Neurol, 68(1): 90-93.
[12] Guerreiro, R., Ross, O.A., Kun-Rodrigues, C., et al. (2018) Investigating the Genetic Architecture of Dementia with Lewy Bodies: A Two-Stage Genome-Wide Association Study. Lancet Neu-rol, 17(1): 64-74.
[13] Liu, Q., Jia, W.L., Liu, C., et al. (2021) Clinical Research Progress of Dementia with Lewy Bodies. Chinese Journal of Rehabilitation Medicine, 36(03): 364-369.
[14] Haider, A., Spurling, B.C. and Sánchez-Manso, J.C. (2022) Lewy Body Dementia. 2021 Jul 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–.
[15] Toledo, J.B., Gopal, P., Raible, K., et al. (2016) Pathological Alpha-Synuclein Distribution in Subjects with Coincident Alzheimer'sand Lewy Body Pathology. Acta Neuropathol, 131(3): 393-409.
[16] Jellinger, K.A. (2018) Dementia with Lewy Bodies and Parkinson's disease-Dementia: Current Concepts and Controversies. J Neural Transm (Vienna), 125(4): 615-650.
[17] McKeith, I.G., Galasko, D., Kosaka, K., et al. (1996) Consensus Guide-lines for the Clinical and Pathologic Diagnosis of Dementiawith Lewy Bodies (DLB): Report of the Consortium on DLB International Workshop. Neurology, 47:1113-1124.
[18] Neurodegenerative Disease Professional Committee of Chinese Society of Microcirculation. Expert Consensus on Diagnosis and Treatment of Dementia with Lewy Body in China. Chinese Journal of Geriatrics, 2015, 34(4): 339-344.
[19] Neurodegenerative Disease Professional Committee of Chinese Society of Microcirculation. Expert Consensus on Diagnosis and Treatment of Dementia with Lewy Body in China. Chinese Journal of Geriatrics, 2021, 40(12): 1473-1484.
[20] Xiao, Z.L. and Xu, L.J. (2015) Research Progress on Neuroimaging-Related Markers for Amyloid Angiopathy of the Brain. Chinese Journal of Neuropsychiatric Diseases, 41(6): 377-379.
[21] Hu, W.Z., Gan, J.H., Liu, S., et al. (2019) Symptoms of Autonomic Dysfunction in Alzheimer's Disease and Dementia with Lewy Bodies. Alzheimer's Disease and Related Diseases, 2019, 2(01): 245-249.
[22] Yao, C.J. (2018) Value of TMS in Differential Diagnosis of AD and DLB. China Urban and Rural Enterprise Health, 33(07):48-49.
[23] Sun, D.Y., Tian, A., Yao, Q., et al. (2016) Comparison of White Matter Fiber Bundle Changes in Dementia with Lewy Body and Parkinson's Disease. Journal of Clinical Neurology, 29(06): 429-432.
[24] Dai, J.Y., Zhao, M., Zhang, J., et al. (2020) A Case of Dementia with Lewy Bodies was Reported and Analyzed in the Literature. Clinical Research of Traditional Chinese Medicine, 12(27): 27-28.
[25] Yang, T., Wang, J.J. and Cheng, H.L. (2020) Experimental Research Progress of Acupuncture in the Treatment of Vascular Dementia. Journal of Liaoning University of Traditional Chinese Medicine, 22(12): 110-113.
[26] Ma, L., Wang, S.T. and Liu, Z. (2017) Effects of Electroacupuncture Frontal Region on Behavior and Camp-PPA -CREB Signaling Pathway in Brain in Rats with Vascular Dementia. Clinical Journal of Acupuncture, 33(01): 50-52.
[27] Huang, X.J., Jiang, W.W., Jia, C.L., et al. (2015) Effects of Electricity on Learning and Memory Function, Apoptosis and Synaptophysin Expression in Hippocampal Nerve Cells in Rats with Vascular Dementia. Chinese Journal of Gerontology, 35(17): 4786-4788.
[28] Yang, X.B., Wang, J.H., An, H.Q., et al. (2019) Effect of Warm Tone Acupuncture on Expression of Nicotinic Acetylcholine Receptors in Hippocampal Nicotinic Receptors in Rats with Vascular Dementia. Acupuncture Research, 44(10): 709-714.
[29] Beversdorf, D.Q., Warner, J.L., Davis, R.A., et al. (2004) Donepezil in the Treatment of Dementia with Lewy Bodies. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 12(5), 542-544.
[30] Ikeda, M.., Mori, E., Matsuo, K., et al. (2015) Donepezil for Dementia with Lewy bodies: A Randomized, Placebo-Controlled, Confirmatory Phase III Trial. Alzheimer's Research and Therapy, 7(1): 4.4.
[31] Mori, E., Ikeda, M., Nagai, R., et al. (2015) Long-term Donepezil Use for Dementia with Lewy Bodies: Results from an Open-Label Extension of Phase III Trial. Alzheimer's Research and Therapy, 7(1): 5.
[32] Stinton, C., McKeith, I., Taylor, J.P., et al. (2015) Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta­Analysis. Am J Psychiatry, 172: 731-42.
[33] Wang, H.F., Yu, J.T., Tang, S.W., et al. (2015) Efficacy and Safety of Cholinesterase Inhibitors and Memantine in Cognitive Impairment in Parkinson's Disease, Parkinson’s Disease Dementia, and Dementia with Lewy Bodies: Systematic Review with Meta­Analysis and Trial Sequential Analysis. J Neurol Neurosurg Psychiatry, 86: 135-43.
[34] Nour, J.M., Chouliaras, L. and Hickey, L. (2016) High dose Rivastigmine in the Symptom Management of Lewy Body Dementia. BMJ Case Reports, bcr2016217240.
[35] Edwards, K., Royall, D., Hershey, L., et al. (2007) Efficacy and Safety of Galantamine in Patients with Dementia with Lewy Bodies: A 24-week Open-label Study. Dementia and Geriatric Cognitive Disorders, 23(6): 401-405.
[36] Wesnes, K.A., Aarsland, D., Ballard, C., et al. (2015) Memantine Improves Attention and Episodic Memory in Parkinson's Disease Dementia and Dementia with Lewybodies .IntJGeriatrPsychiatry, 30(1): 46-54.
[37] Ikeda, M., Mori, E., Kosaka, K., et al. (2013) Donepezil-DLB Study Investigators.Long-Term Safety and Efficacy of Donepezil in Patients with Dementia with Lewy Bodies: Results From a 52-Week, Open-Label, Multicenter Extension Study. Dementia and Geriatric Cognitive Disorders, 36(3–4): 229-241.
[38] Mori, E., Ikeda, M., Nagai, R., et al. (2015) Long-Term Donepezil Use for Dementia with Lewy Bodies: Results from an Open-Label Extension of Phase III Trial. Alzheimer's Research and Therapy, 7(1): 5.
[39] Tanaka, M. and Kita, T. (2005) Paroxetine and Improvement of Visual Hallucinations in Patients with Dementia with Lewy Bodies. Journal of the American Geriatrics Society, 53(4):732-733.
[40] Culo, S., Mulsant, B.H., Rosen, J., et al. (2010) Treating Neuropsychiatric Symptoms in Dementia with Lewy Bodies: A Randomized Controlled-Trial. Alzheimer Disease and Associated Disorders, 24(4): 360-364.
[41] Grace, J., Daniel, S., Stevens, T., et al. (2001) Long-Term Use of Rivastigmine in Patients with Dementia with Lewy Bodies: An Open-Label Trial. International Psychogeriat- rics, 13(2), 199-205.
[42] Emre, M., Tsolaki, M., Bonuccel, L., et al. (2010) Memantine Forpatients with Parkinson's Disease Dementia or Dementia with Lewybodies: Arandomised, Doubleblind, Placebo- Controlled Trial. Lancet Neurol, 9(10): 969-977.
[43] Larsson, V., Aarsland, D., Ballard, C., et al. (2010) The Effect of Memantine on Sleep Behaviour in Dementia with Lewy Bodies and Parkinson's Disease Dementia. International Journal of Geriatric Psychiatry, 25(10):1030-1038.
[44] Stubendorff, K., Larsson, V., Ballard, C., et al. (2014) Treatment Effect of Memantine on Survival in Dementia with Lewy Bodies and Parkinson's Disease With Dementia: A Prospective Study. BMJ Open, 4(7): e005158.
[45] Mathys, M.L., McCarrell, J., Sleeper, R.B., et al. (2013) Visual Hallucinations Treated with the Reinitiation of Memantine in a Patient with Lewy Body Dementia. The Annals of Pharmacotherapy, 47(2): e10
[46] Lapid, M.I., Kuntz, K.M., Mason, S.S., et al. (2017) Efficacy, Safety and Tolerability of Armodafinil Therapy for Hypersomnia Associated with Dementia with Lewy Bodies: A Pilot Study. Dementia and Geriatric Cognitive Disorders, 43(5-6):269-280.
[47] Prado, E., Paholpak, P., Ngo, M., et al. (2012) Agitation and Psychosis Associated with Dementia with Lewy Bodies Exacerbated by Modafinil Use. American Journal of Alzheimer’s Disease and Other Dementias, 27(7): 468-473.
[48] Kobayashi, R., Matsumoto, Y., Hayashi, H., et al. (2017) Neuroleptic Malignant Syndrome Following Quetiapine Treatment in a Patient with Dementia with Lewy Bodies. Asian Journal of Psychiatry, 30: 173-174.
[49] Cummings, J.L., Street, J., Masterman, D., et al. (2002) Efficacy of Olanzapine in the Treatment of Psychosis in Dementia with Lewy Bodies. Dementia and Geriatric Cognitive Disorders, 13(2): 67-73.
[50] Lee, C. and Shen, Y.C. (2017) Aripiprazole Improves Psychotic, Cognitive, and Motor Symptoms in A Patient with Lewy Body Dementia. Journal of Clinical Psychopharmacology, 37(5): 628–630.
[51] Sugawara, K.Y. and Shimizu, T. (2019) Aripiprazole for the Treatment of Psychotic Symptoms in Patients with Dementia with Lewy Bodies: A Case Series. Neuropsychiatric Disease and Treatment, 15: 543–547.
[52] Massironi, G., Galluzzi, S. and Frisoni, G.B. (2003) Drug Treatment of REM Sleep Behavior Disorders In Dementia with Lewy Bodies. International Psychogeriatrics, 15(4): 377-383.
[53] Bhamra, M., Rajkumar, A.P., Ffytche, D.H., et al. (2018) Successful Management of Persistent Distressing Neuropsychiatric Symptoms by Clozapine in A Patient Suffering from Dementia with Lewy Bodies. BMJ Case Reports.
[54] Kuring, J.K., Mathias, J.L. and Ward, L. (2018) Prevalence of Depression, Anxiety and PTSD in People with Dementia: A Systematic Review and Meta­Analysis. Neuropsychol Rev 2018, 28: 393–416.
[55] Reijnders, J.S., Ehrt, U., Weber, W.E., et al. (2008) A Systematic Review of Prevalence Studies of Depression in Parkinson's Disease. Mov Disord, 23: 183–89.
[56] Watts, K.E., Storr, N.J., Barr, P.G. and Rajkumar, A.P. (2022) Systematic Review of Pharmacological Interventions for People with Lewy Body Dementia. Aging Ment Health. Feb 2:1-14. 
[57] McKeith, I.G., Boeve, B.F., Dickson, D.W., et al. (2017) Diagnosis and Management of Dementia with Lewy Bodies: Fourth Consensus Report of the Dementia with Lewy Bodies Consortium. Neurology, 89: 88–100.
[58] Murata, M., Odawara, T., Hasegawa, K., et al. (2018) Adjunct Zonisamide to Levodopa for DLB Parkinsonism: A Randomized Double-Blind Phase 2 Study. Neurology, 90(8): e664-e672.
[59] Fujishiro, H. (2014) Effects of Gabapentin Enacarbil on Restless Legs Syndrome and Leg Pain in Dementia with Lewy Bodies. Psychogeriatrics: The Official Journal of the Japanese Psychogeriatric Society, 14(2): 132-134.
[60] Lucetti, C., Logi, C., DelDotto, P., et al. (2010) Levodopa Response in Dementia with Lewy Bodies: A 1-Year Follow-Up Study. Parkinsonism and Related Disorders, 16(8): 522-526.
[61] Goldman, J.G., Goetz, C.G., Brandabur, M., et al. (2008) Effectsof Dopaminergic Medicationson Psychosisand Motor Functionin Dementia with Lewy Bodies. Mov Disord, 23 (15): 2248-2250.
[62] Gibbons, C.H., Schmidt, P., Biaggioni, I., et al. (2017) The Recommendations of A Consensus Panel for the Screening, Diagnosis, and Treatment of Neurogenic Orthostatic Hypotension and Associated Supine Hypertension. J Neurol, 264(8): 1567-1582.
[63] Larsson, V., Torisson, G., Bulow, M. and Londos, E. (2017) Effects of Carbonated Liquid on Swallowing Dysfunction in Dementia with Lewy Bodies and Parkinson’s Disease Dementia. Clinical Interv Aging, 12: 1215-22.
[64] Fasano, A., Visanji, N.P., Liu, L.W.C., et al. (2015) Gastrointestinal Dysfunction in Parkinson's Disease. Lancet Neurol, 14: 625-39.
[65] Morrin, H., Fang, T., Servant, D., et al. (2018) Systematic Review of the Efficacy of Non-Pharmaco-Logical Interventions in People with Lewy Body Dementia. International Psychogeriatrics, 30: 395-407.
[66] Rasmussen, K.G., Russell, J.C., Kung, S., et al. (2003) Electroconvulsive Therapy for Patients with Major Depression and Probable Lewy Body Dementia. The Journal of ECT, 19, 103-109.
[67] Kim, H.J., Jeon, B., Lee, J.Y., et al. (2017) Can Deep Brain Stimulation Be a Therapeutic Option for Parkinson's Disease Dementia? Neurology and Clinical Neuroscience, 5: 3 -7.
[68] Elder, G.J. (2016) Effects of Transcranial Direct Current Stimulation upon Attention and Visuoperceptual Function in Lewy Body Dementia: A Preliminary Study. International Psychogeriatrics, 28: 341-347.
[69] Armstrong, M.J. (2019) Lewy Body Dementias. CONTINUUM: Lifelong Learning in Neurology, 25(1):128-146.

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