The Mechanism of Scutellarin on Pancreatic Cancer Cells was Studied Based on Network Pharmacology

Zixin Xu; Faping Song; Shuangquan Wang

doi:10.23977/medcm.2023.050210

The Mechanism of Scutellarin on Pancreatic Cancer Cells was Studied Based on Network Pharmacology

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DOI: 10.23977/medcm.2023.050210 | Downloads: 10 | Views: 373

Author(s)

Zixin Xu ¹, Faping Song ¹, Shuangquan Wang ^1,2

Affiliation(s)

¹ Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
² The Third Affiliated Hospital of Shaanxi University of Chinese Medicine, Xi'an XD Group Hospital, Xi'an, Shaanxi, 710077, China

Corresponding Author

Shuangquan Wang

ABSTRACT

Objective: To explore the potential target and mechanism of action of scutellarin in the treatment of pancreatic cancer by network pharmacology. Methods: Swiss Target Prediction was used to extract the potential target of scutellarin. The targets of pancreatic cancer were obtained from Gene Cards and OMIM databases. R software was used to analyze and obtain common targets of drugs and diseases. Cytoscope3.7.2 software plug-in CtyoNCA topology was used to establish the protein interaction (PPI) network diagram using STRING database to analyze the key targets of drug therapy in disease. R software was used for GO enrichment analysis. The Metascape website was used for enrichment analysis of KEGG pathway to predict the signaling pathway of scutellarin in the treatment of pancreatic cancer. Results: A total of 91 targets related to scutellarin in the treatment of pancreatic cancer were screened, including TNF, EGFR, CASP3, HSP90AA1, HRAS, etc. By GO enrichment analysis, 932 items were obtained, including 797 BP, 58 CC, and 77 MF. Through KEGG enrichment analysis, we obtained 13 tumor-related KEGG pathways, including anti-folate resistance, C-type lectin receptor signaling pathway, nitrogen metabolism, galactose metabolism, cancer pathway, neural active ligand-receptor interaction, purine metabolism, etc. Conclusion: This study indicates that scutellarin can act on pancreatic cancer through multiple targets and pathways. Scutellarin has a potential therapeutic effects on pancreatic cancer. This study provides a new basis for curcumin in the treatment of pancreatic cancer.

KEYWORDS

Pharmacology of network, Scutellarin, Pancreatic cancer, PPI, GO, KEGG

CITE THIS PAPER

Zixin Xu, Faping Song, Shuangquan Wang, The Mechanism of Scutellarin on Pancreatic Cancer Cells was Studied Based on Network Pharmacology. MEDS Chinese Medicine (2023) Vol. 5: 75-82. DOI: http://dx.doi.org/10.23977/medcm.2023.050210.

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The Mechanism of Scutellarin on Pancreatic Cancer Cells was Studied Based on Network Pharmacology

Author(s)

Affiliation(s)

Corresponding Author

ABSTRACT

KEYWORDS

CITE THIS PAPER

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