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  4. Vol 5, Issue 3, 2023

Meta Analysis of Traditional Chinese Medicine in Treating Cholecystolithiasis and Network Pharmacological Analysis of High-Frequency Drug Pairs

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DOI: 10.23977/medcm.2023.050304 | Downloads: 112 | Views: 685

Author(s)

Zhao Linjing 1, Yin Taotao 1, Wang Guotai 2, Yang Xingwu 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, 712046, China
2 Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, China

Corresponding Author

Yang Xingwu

ABSTRACT

Objective to explore the clinical efficacy of Traditional Chinese medicine (TCM) in the treatment of gallstones, and to study the mechanism of high-frequency drug pairs (Bupleurum chinense and Lysimachia charistinae) in the treatment of gallstones. Methods: A computer search was conducted to search The Cochrane Library, CNKI, VIP, Wanfang, CBM, PubMed, and Web of Science databases for meta-analysis of randomized controlled studies on TCM treatment of gallstones in recent ten years. According to the results of the heterogeneity test, appropriate models were selected to make the forest map and funnel map, and the literature quality was evaluated. Network pharmacologic analysis was performed for the drug pairs (Bupleurum chinense and Pennisetum chinens) that appeared most frequently in the included literature. Chemical components and targets of the two traditional Chinese medicines in the treatment of gallstones were screened out, GO analysis and KEGG analysis were performed, and the potential mechanism of action of the two traditional Chinese medicines in the treatment of gallstones was discussed. Results: Meta-analysis showed that there was a significant difference in the effective rate between traditional Chinese medicine and conventional medicine in the treatment of gallstones. After network pharmacological analysis, there were 14 chemical components and 90 targets in the treatment of gallstones by S. chinensis and Bupleurum. GO analysis revealed 578 biological processes, 53 cell compositions, and 104 molecular functions. KEGG analysis showed that the biological pathway of Bupleurum and Radix monstris in the treatment of gallstones involved cancer pathway and TNF signaling pathway. Conclusion: TCM treatment of gallstones can improve clinical efficacy, and TCM treatment of gallstones has important clinical significance. Gallstone is a common biliary system disease in China, and its incidence is increasing year by year [1]. Gallstones can lead to gallbladder cancer [2]. Gallbladder cancer is a highly malignant cancer. Therefore, attention should be paid to the treatment of gallstones. However, there are some sequelae in the surgical treatment of gallstones, such as the recurrence of gallstones, bile duct injury, postoperative infection, etc. [3]. Ursodeoxycholic acid, anti-inflammatory cholagogue tablets, Dankang capsules, and other commonly used drugs in the clinical treatment of gallstones are difficult to solve the problem of the root. The author believes that the treatment based on syndrome differentiation of traditional Chinese medicine, combined with the patient's physique, can not only achieve the effect of dissolving and removing stones, but also eliminate and prevent the recurrence of stones from the root. Now the author uses statistical analysis to evaluate the clinical efficacy of traditional Chinese medicine in the treatment of cholecystolithiasis, and studies the potential mechanism of high-frequency traditional Chinese medicine based on the results of meta-analysis, to broaden new ideas for clinical conservative treatment of cholecystolithiasis.

KEYWORDS

Gallstone, Traditional Chinese Medicine (TCM), Meta Analysis, Network Pharmacologic Analysis

CITE THIS PAPER

Zhao Linjing, Yin Taotao, Wang Guotai, Yang Xingwu, Meta Analysis of Traditional Chinese Medicine in Treating Cholecystolithiasis and Network Pharmacological Analysis of High-Frequency Drug Pairs. MEDS Chinese Medicine (2023) Vol. 5: 25-36. DOI: http://dx.doi.org/10.23977/medcm.2023.050304.

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