Author(s)

Qi He ^1,2, Meng Jin ^1,2, Lei Huang ^1,2, Jianbin Ma ², Rui Zhang ²

Affiliation(s)

¹ Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
² Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China

Corresponding Author

Rui Zhang

ABSTRACT

Osteoarthritis (OA) is a degenerative joint disease caused by a variety of factors, which is highly prevalent in the elderly population and is mainly characterized by articular cartilage degeneration and surrounding bone regeneration, with clinical manifestations of repeated joint swelling, pain, stiffness and joint deformity at a later stage. OA is a chronic disease that gives elderly patients and their relatives many life inconveniences and economic pressures. According to the practicability and effectiveness of treatment in elderly patients, the advantages of traditional Chinese medicine stand out. At present, the active ingredients of traditional Chinese medicine are divided into saponins, saponins, alkaloids and polyphenols, of which saponins are the main active ingredients of traditional Chinese medicine. This paper summarizes the research results and progress of icariin, ginsenoside Rg1, astragaloside IV, clematis saponins and other saponins in the treatment of osteoarthritis.

KEYWORDS

Oteoarthritis, active ingredients of saponins, mechanism of action, research progress

CITE THIS PAPER

Qi He, Meng Jin, Lei Huang, Jianbin Ma, Rui Zhang, Progress in research on mechanism of saponins in treating osteoarthritis. MEDS Chinese Medicine (2023) Vol. 5: 64-68. DOI: http://dx.doi.org/10.23977/medcm.2023.050309.

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